Evidence map›Paper›PMID 34260303›Full record

ArticleApplied and environmental microbiology2021

Proteome, Bioinformatic, and Functional Analyses Reveal a Distinct and Conserved Metabolic Pathway for Bile Salt Degradation in the

Franziska M Feller, Lars Wöhlbrand, Johannes Holert, Vanessa Schnaars, Lea Elsner, William W Mohn, Ralf Rabus, Bodo Philipp

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Current Trends and Perspectives in Microbial Bioconversions of Steroids.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  5. Comparative Analysis of Bile-Salt Degradation inApplied and environmental microbiology · 2021
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Franziska M FellerMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Lars WöhlbrandGeneral and Molecular Microbiology, Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.
Johannes HolertMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Vanessa SchnaarsGeneral and Molecular Microbiology, Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.
Lea ElsnerMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, Westfälische Wilhelms-Universität Münster, Münster, Germany.
William W MohnDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbiagrid.17091.3e, Vancouver, Canada.ORCID 0000-0002-6509-746X
Ralf RabusGeneral and Molecular Microbiology, Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.ORCID 0000-0001-5536-431X
Bodo PhilippMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, Westfälische Wilhelms-Universität Münster, Münster, Germany.ORCID 0000-0002-6424-0770
University of Münster · DECarl von Ossietzky Universität Oldenburg · DEUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bile salts are amphiphilic steroids with digestive functions in vertebrates. Upon excretion, bile salts are degraded by environmental bacteria. Degradation of the bile salt steroid skeleton resembles the well-studied pathway for other steroids, like testosterone, while specific differences occur during side chain degradation and the initiating transformations of the steroid skeleton. Of the latter, two variants via either Δ

Indexed as

Bacterial ProteinsBile Acids and SaltsBiodegradation, EnvironmentalComputational BiologyMetabolic Networks and PathwaysProteomeSphingomonadaceaeBacterial ProteinsBile Acids and SaltsProteomebile saltproteomicsSphingomonadaceaesteroid degradation

Identifiers

PMID34260303
PMCPMC8432579
OpenAlexW3179338758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.