Evidence map›Paper›PMID 34260010›Full record

ArticleGeroScience2021

The hidden interplay between sex and COVID-19 mortality: the role of cardiovascular calcification.

Alberto Cereda, Marco Toselli, Anna Palmisano, Davide Vignale, Riccardo Leone, Valeria Nicoletti, Chiara Gnasso, Antonio Mangieri, Arif Khokhar, Gianluca Campo and 25 more

Open access · hybridAbstract read
In one paragraph

Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Correlation between coronary artery calcification and COVID-19.Caspian journal of internal medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 12 institutions in 1 country.

Alberto CeredaGVM Care & Research Maria Cecilia Hospital, Cotignola, Italy. alberto.cereda@email.it.
Marco ToselliGVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.
Anna PalmisanoIRCCS San Raffaele Scientific Institute, Milan, Italy.
Davide VignaleIRCCS San Raffaele Scientific Institute, Milan, Italy.
Riccardo LeoneIRCCS San Raffaele Scientific Institute, Milan, Italy.
Valeria NicolettiIRCCS San Raffaele Scientific Institute, Milan, Italy.
Chiara GnassoIRCCS San Raffaele Scientific Institute, Milan, Italy.
Antonio MangieriGVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.
Arif KhokharGVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.
Gianluca CampoAzienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Alessandra ScocciaAzienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Matteo BertiniAzienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Marco LoffiOspedale di Cremona, Cremona, Italy.
Pietro SergioOspedale di Cremona, Cremona, Italy.
Daniele AndreiniCentro Cardiologico Monzino IRCCS, Milan, Italy.
Gianluca PontoneCentro Cardiologico Monzino IRCCS, Milan, Italy.
Gianmarco IannopolloOspedale Maggiore, Bologna, Italy.
Tommaso NanniniOspedale Maggiore, Bologna, Italy.
Davide IppolitoSan Gerardo Hospital, Monza, Italy.
Giacomo BellaniSan Gerardo Hospital, Monza, Italy.
Gianluigi PatelliASST Bolognini Hospital, Bergamo Est, Seriate, Italy.
Francesca BesanaASST Bolognini Hospital, Bergamo Est, Seriate, Italy.
Luigi VignaliParma University Hospital, Parma, Italy.
Nicola SverzellatiParma University Hospital, Parma, Italy.
Mario IannacconeSan Giovanni Bosco Hospital, ASL Citta di Torino, Turin, Italy.
Paolo Giacomo VaudanoSan Giovanni Bosco Hospital, ASL Citta di Torino, Turin, Italy.
Giuseppe Massimo SangiorgiUniversità degli Studi di Roma "Tor Vergata", Roma, Italy.
Piergiorgio TurchioGuglielmo da Saliceto Hospital, Piacenza, Italy.
Alberto MonelloGuglielmo da Saliceto Hospital, Piacenza, Italy.
Gabriele TumminelloVita-Salute San Raffaele University, Milan, Italy.
Aldo Pietro MaggioniGVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.
Claudio RapezziGVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.
Antonio ColomboGVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.
Francesco GianniniGVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.
Antonio EspositoIRCCS San Raffaele Scientific Institute, Milan, Italy.
Maria Cecilia Hospital · ITVita-Salute San Raffaele University · ITIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleAzienda Ospedaliera Bolognini Seriate · ITAzienda Ospedaliera San Gerardo · ITCentro Cardiologico Monzino · ITGuglielmo da Saliceto Hospital · ITIstituti Ospitalieri di Cremona · ITOspedale Maggiore Carlo Alberto Pizzardi · ITOspedale San Giovanni Bosco · ITUniversity of Parma · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent clinical and demographical studies on COVID-19 patients have demonstrated that men experience worse outcomes than women. However, in most cases, the data were not stratified according to gender, limiting the understanding of the real impact of gender on outcomes. This study aimed to evaluate the disaggregated in-hospital outcomes and explore the possible interactions between gender and cardiovascular calcifications. Data was derived from the sCORE-COVID-19 registry, an Italian multicentre registry that enrolled COVID-19 patients who had undergone a chest computer tomography scan on admission. A total of 1683 hospitalized patients (mean age 67±14 years) were included. Men had a higher prevalence of cardiovascular comorbidities, a higher pneumonia extension, more coronary calcifications (63% vs.50.9%, p<0.001), and a higher coronary calcium score (391±847 vs. 171±479 mm

Indexed as

COVID-19Vascular CalcificationAgedAged, 80 and overAorta, ThoracicFemaleHumansMaleRNA, ViralSARS-CoV-2RNA, ViralCOVID-19Lung CT; Cardiovascular calcificationsSars-CoV2Sex bias

Identifiers

PMID34260010
PMCPMC8278366
OpenAlexW3180635886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.