Evidence map›Paper›PMID 34260003›Full record

ArticleNeurochemical research2021

Resveratrol Protects SH-SY5Y Cells Against Oleic Acid-Induced Glucolipid Metabolic Dysfunction and Cell Injuries Via the Wnt/β-Catenin Signalling Pathway.

Jing-Xian Xu, Ke Fang, Xin-Ran Gao, Sen Liu, Jin-Fang Ge

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jing-Xian XuSchool of Pharmacy, Anhui Medical University, 81 Mei-Shan Road, Hefei, 230032, Anhui, China.
Ke FangSchool of Pharmacy, Anhui Medical University, 81 Mei-Shan Road, Hefei, 230032, Anhui, China.
Xin-Ran GaoSchool of Pharmacy, Anhui Medical University, 81 Mei-Shan Road, Hefei, 230032, Anhui, China.
Sen LiuSchool of Pharmacy, Anhui Medical University, 81 Mei-Shan Road, Hefei, 230032, Anhui, China.
Jin-Fang GeSchool of Pharmacy, Anhui Medical University, 81 Mei-Shan Road, Hefei, 230032, Anhui, China. gejinfang@ahmu.edu.cn.
Anhui Provincial Center for Disease Control and Prevention · CNAnhui Medical University · CNMinistry of Education of the People's Republic of China · CN

Funding

Anhui Medical University Basic and Clinical Cooperative Research Promotion Plan 2020xkjT036anhui provincial education quality engineering project 2020jyxm0868National Natural Science Foundation of China 81870403
6 · The paper itself

Abstract

Resveratrol (RES) is a polyphenol with diverse beneficial biological and pharmacological activities, and our previous results have demonstrated its neuroprotective effects in several metabolic diseases, including non-alcoholic fatty liver disease. The aim of the present study is to investigate the potential effect of RES against oleic acid (OA)-induced cell injuries in SH-SY5Y cells and explore the possible mechanism. Based on the dose- and time-dependent effects of OA on cell proliferation and LDH release, SH-SY5Y cells were challenged with OA and incubated with or without RES (10

Indexed as

Cell Line, TumorCell ProliferationDose-Response Relationship, DrugGlucoseHumansIntercellular Signaling Peptides and ProteinsLipid MetabolismNeuroprotective AgentsOleic AcidOxidative StressResveratrolWnt Signaling PathwayDKK1 protein, humanGlucoseIntercellular Signaling Peptides and ProteinsNeuroprotective AgentsOleic AcidResveratrolInsulin resistanceOleic acidOxidative stressResveratrolWnt/β-catenin pathway

Identifiers

PMID34260003
OpenAlexW3178386469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.