Evidence map›Paper›PMID 34260002›Full record

ArticleNeurochemical research2021

Antioxidant Effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Nitrohydroxytyrosol in a Rat MPP

Gabriela Pérez-Barrón, Sergio Montes, Yoshajandith Aguirre-Vidal, Marti Santiago, Elena Gallardo, José Luis Espartero, Camilo Ríos, Antonio Monroy-Noyola

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Gabriela Pérez-BarrónLaboratorio de Neuroprotección, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001 Col. Chamilpa, CP: 62209, Cuernavaca, Morelos, Mexico.
Sergio MontesDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, M.V.S., Ciudad de México, Mexico.
Yoshajandith Aguirre-VidalLaboratorio de Neuroprotección, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001 Col. Chamilpa, CP: 62209, Cuernavaca, Morelos, Mexico.
Marti SantiagoDepartamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain.
Elena GallardoDepartamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain.
José Luis EsparteroDepartamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain.
Camilo RíosDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, M.V.S., Ciudad de México, Mexico.
Antonio Monroy-NoyolaLaboratorio de Neuroprotección, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001 Col. Chamilpa, CP: 62209, Cuernavaca, Morelos, Mexico. amonroy@uaem.mx.
Universidad Autónoma del Estado de Morelos · MXUniversidad de Sevilla · ESInstituto Nacional de Neurología y Neurocirugía · MX

Funding

SEP/CONACYT 257092
6 · The paper itself

Abstract

3,4-Dihydroxyphenyl ethanol, known as hydroxytyrosol (HTy), is a phenylpropanoid found in diverse vegetable species. Several studies have demonstrated that HTy is a potent antioxidant. Thus, our study is aimed to evaluate the antioxidant effect of HTy and its derivatives, hydroxytyrosol acetate (HTyA) and nitrohydroxytyrosol (HTyN), in a model of oxidative stress induced by 1-methyl-4-phenylpyridinium (MPP

Indexed as

1-Methyl-4-phenylpyridiniumAcetatesAdministration, IntravenousAnimalsAntioxidantsCatecholsCorpus StriatumDopamineLipid PeroxidationMaleOxidative StressParkinsonian DisordersPhenylethyl AlcoholRatsRats, WistarTreatment Outcome1-Methyl-4-phenylpyridinium3,4-dihydroxyphenylethanolAcetatesAntioxidantsCatecholsDopaminehydroxytyrosyl acetatePhenylethyl AlcoholDopamineGSH/GSSGHydroxytyrosolLipid peroxidationOxidative stressParkinson’s disease

Identifiers

PMID34260002
OpenAlexW3178269476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.