Evidence map›Paper›PMID 34259925›Full record

ArticleAmino acids2021

Racemization-free synthesis of Nα-2-thiophenoyl-phenylalanine-2-morpholinoanilide enantiomers and their antimycobacterial activity.

Lea Mann, Markus Lang, Philipp Schulze, Jan Henrik Halz, René Csuk, Sophie Hoenke, Rüdiger W Seidel, Adrian Richter

Abstract read
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Broad-Spectrum In Vitro Activity ofAntibiotics (Basel, Switzerland) · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Microbiology spectrum · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lea MannInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany.
Markus LangInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany.
Philipp SchulzeMax-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany.
Jan Henrik HalzInstitut für Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes Str. 2, 06120, Halle (Saale), Germany.
René CsukInstitut für Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes Str. 2, 06120, Halle (Saale), Germany.ORCID http://orcid.org/0000-0001-7911-290X
Sophie HoenkeInstitut für Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes Str. 2, 06120, Halle (Saale), Germany.
Rüdiger W SeidelInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany.ORCID http://orcid.org/0000-0003-3438-4666
Adrian RichterInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany. adrian.richter@pharmazie.uni-halle.de.ORCID http://orcid.org/0000-0002-0062-7896

Funding

Deutsche Forschungsgemeinschaft 432291016
6 · The paper itself

Abstract

Nα-2-thiophenoyl-D-phenylalanine-2-morpholinoanilide (MMV688845, IUPAC: N-(1-((2-morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide) from the Pathogen Box

Indexed as

Calorimetry, Differential ScanningChromatography, High Pressure LiquidMicrobial Sensitivity TestsMycobacteriumPhenylalanineSpectrum AnalysisStereoisomerismPhenylalanineAmino acidAntimycobacterial activityCrystal structureEnantioselective activityGSK1055950AMMV688845Phenylalanine amidesRacemization-free synthesis

Identifiers

PMID34259925
PMCPMC8325651

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.