ArticleInvestigative ophthalmology & visual science2021
Composition of the Inner Nuclear Layer in Human Retina.
Article in Investigative ophthalmology & visual science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Lysosomal Membrane Protein SCARB2 Mediates the Pathogenesis of Diabetic Retinopathy Through the MAPK/ERK/MMP9 Signaling Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Localization of Ceramide Synthase 5 in Mouse Retina.The Journal of comparative neurology · 2026Article
- Associations between retinal morphological features and risk of depression and anxiety disorders.BMC medicine · 2026Article
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- Microglial phagocytosis of bipolar cells triggers inner retinal degeneration in Rs1-KO mice.Cell communication and signaling : CCS · 2026Article
- A scRNA-seq reference contrasting living and early post-mortem human retina across diverse donor states.Human genomics · 2025Article
- Quantitative assessment of retinal attenuation and backscattering in OCT imaging using iterative layer-based analysis.Biomedical optics express · 2025Article
- Immunohistochemistry and Spatial Density of Müller Cells in the Human Fovea.Investigative ophthalmology & visual science · 2025Article
- Bile duct ligation impairs visual acuity in rats by ammonia- and bilirubin-induced retinal degeneration.Acta pharmacologica Sinica · 2025Article
- Review
- A Comparative Analysis of Models for AAV-Mediated Gene Therapy for Inherited Retinal Diseases.Cells · 2024Review
- A Mathematical Model of Interstitial Fluid Flow and Retinal Tissue Deformation in Macular Edema.Investigative ophthalmology & visual science · 2024Article
- Melanopsin-mediated amplification of cone signals in the human visual cortex.Proceedings. Biological sciences · 2024Article
- Spatial Analysis Reveals Vascular Changes in Retinal and Choroidal Vessel Perfusion in Intermediate AMD With Reticular Pseudodrusen.Investigative ophthalmology & visual science · 2024Article
- Unusual morphology of foveal Müller glia in an adult human born pre-term.Frontiers in cellular neuroscience · 2024Article
- Prevalence and Distribution of Macular Fluid with Central Retinal Artery Occlusion and Anterior Ischaemic Optic Neuropathy [Response to Letter].Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Article
- Diabetic Müller-Glial-Cell-Specific Il6ra Knockout Mice Exhibit Accelerated Retinal Functional Decline and Thinning of the Inner Nuclear Layer.Investigative ophthalmology & visual science · 2023Article
- Derivation of human retinal cell densities using high-density, spatially localized optical coherence tomography data from the human retina.The Journal of comparative neurology · 2023Article
- Nonarteritic Anterior Ischemic Optic Neuropathy: Cystic Change in the Inner Nuclear Layer Caused by Edema and Retrograde Maculopathy.Ophthalmology science · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to measure the composition of the inner nuclear layer (INL) in the central and peripheral human retina as foundation data for interpreting INL function and dysfunction. Methods: Six postmortem human donor retinas (male and female, aged 31-56 years) were sectioned along the temporal horizontal meridian. Sections were processed with immunofluorescent markers and imaged using high-resolution, multichannel fluorescence microscopy. The density of horizontal, bipolar, amacrine, and Müller cells was quantified between 1 and 12 mm eccentricity with appropriate adjustments for postreceptoral spatial displacements near the fovea. Results: Cone bipolar cells dominate the INL a with density near 50,000 cells/mm2 at 1 mm eccentricity and integrated total ∼10 million cells up to 10 mm eccentricity. Outside central retina the spatial density of all cell populations falls but the neuronal makeup of the INL remains relatively constant: a decrease in the proportion of cone bipolar cells (from 52% at 1 mm to 37% at 10 mm) is balanced by an increasing proportion of rod bipolar cells (from 9% to 15%). The proportion of Müller cells near the fovea (17%) is lower than in the peripheral retina (27%). Conclusions: Despite large changes in the absolute density of INL cell populations across the retina, their proportions remain relatively constant. These data may have relevance for interpreting diagnostic signals such as the electroretinogram and optical coherence tomogram.
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