Evidence map›Paper›PMID 34259665›Full record

ArticleCritical care medicine2021

The Impact of Strict Public Health Restrictions on Pediatric Critical Illness.

Aline B Maddux, Kristen Campbell, Alan G Woodruff, Jaime LaVelle, Jeffrey Lutmer, Curt E Kennedy, Marcelo Malakooti, John K McGuire, Lara Shekerdemian, Z Leah Harris and 2 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Association of Asthma With Treatments and Outcomes in Children With Critical Influenza.The journal of allergy and clinical immunology. In practice · 2023
    Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Aline B MadduxDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Kristen CampbellDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Alan G WoodruffDepartment of Anesthesiology, Section of Pediatric Critical Care Medicine, Wake Forest School of Medicine, Winston Salem, NC.
Jaime LaVelleSection of Pediatric Critical Care Medicine, Children's Hospital Colorado, Aurora, CO.
Jeffrey LutmerNationwide Children's Hospital, Columbus, OH.
Curt E KennedyBaylor College of Medicine, Houston, TX.
Marcelo MalakootiDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.
John K McGuireDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.
Lara ShekerdemianBaylor College of Medicine, Houston, TX.
Z Leah HarrisDepartment of Pediatrics, The University of Texas at Austin and Dell Children's Medical Center, Austin, TX.
Michael C McCroryDepartment of Anesthesiology, Section of Pediatric Critical Care Medicine, Wake Forest School of Medicine, Winston Salem, NC.
Todd C CarpenterDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
University of Colorado Denver · USBaylor College of Medicine · USLurie Children's Hospital · USNationwide Children's Hospital · USTexas Children's Hospital · USUniversity of Washington · US

Funding

Functional Outcomes after Prolonged Mechanical Ventilation in ChildrenK23HD096018 · NICHD · UNIVERSITY OF COLORADO DENVER · PI MADDUX, ALINE BERNARD · 2019 to 2023
$807k
NICHD NIH HHS K23 HD096018
6 · The paper itself

Abstract

objectivesTo characterize the impact of public health interventions on the volume and characteristics of admissions to the PICU.

designMulticenter retrospective cohort study.

settingSix U.S. referral PICUs during February 15, 2020-May 14, 2020, compared with the same months during 2017-2019 (baseline). PATIENTS: PICU admissions excluding admissions for illnesses due to severe acute respiratory syndrome coronavirus 2 and readmissions during the same hospitalization.

interventionsNone. MEASUREMENTS AND MAIN

resultsPrimary outcome was admission volumes during the period of stay-at-home orders (March 15, 2020-May 14, 2020) compared with baseline. Secondary outcomes were hospitalization characteristics including advanced support (e.g., invasive mechanical ventilation), PICU and hospital lengths of stay, and mortality. We used generalized linear mixed modeling to compare patient and admission characteristics during the stay-at-home orders period to baseline. We evaluated 7,960 admissions including 1,327 during March 15, 2020-May 14, 2020. Daily admissions and patients days were lower during the period of stay-at-home orders compared with baseline: median admissions 21 (interquartile range, 17-25) versus 36 (interquartile range, 30-42) (p < 0.001) and median patient days 93.0 (interquartile range, 55.9-136.7) versus 143.6 (interquartile range, 108.5-189.2) (p < 0.001). Admissions during the period of stay-at-home orders were less common in young children and for respiratory and infectious illnesses and more common for poisonings, endocrinopathies and for children with race/ethnicity categorized as other/unspecified. There were no differences in hospitalization characteristics except fewer patients received noninvasive ventilation during the period of stay-at-home orders.

conclusionsReductions in PICU admissions suggest that much of pediatric critical illness in younger children and for respiratory and infectious illnesses may be preventable through targeted public health strategies.

Indexed as

AdolescentAge FactorsChildChild, PreschoolCommunicable Disease ControlCOVID-19FemaleHumansInfantIntensive Care Units, PediatricLength of StayMalePandemicsPatient AdmissionRacial GroupsRespiration, Artificial

Identifiers

PMID34259665
PMCPMC8594504
OpenAlexW3179034120

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.