ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022
Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Retinal optical coherence tomography measures in multiple sclerosis: a systematic review and meta-analysis.Annals of clinical and translational neurology · 2024Pooled it
- The Role of Glial Fibrillary Acidic Protein as a Biomarker in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis.Journal of neuroinflammation · 2023Pooled it
- Microvascular impairments detected by optical coherence tomography angiography in multiple sclerosis patients: A systematic review and meta-analysis.Frontiers in neuroscience · 2022Pooled it
- Quantitative ophthalmic posterior segment optical coherence tomography angiography and neurologic conditions: a review.Frontiers in neurologyPooled it
- Serum Glial Fibrillary Acidic Protein and Retinal Neuronal Loss as Additive Prognostic Markers of Disability in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Exercise Training and Biomarkers of Neuroaxonal Injury in Multiple Sclerosis: Narrative Review.International journal of environmental research and public health · 2026Review
- Optical Coherence Tomography Angiography-Derived Peripapillary Vessel Density Findings in Multiple Sclerosis.Journal of clinical medicine · 2026Article
- OCTA-derived retinal microvascular biomarkers in neuromyelitis optica spectrum disorder: clinical potential, methodological challenges, and possible links to astrocytopathy.Frontiers in medicine · 2026Review
- Distinct macular structural and microvascular alterations differentiate neuromyelitis optica spectrum disorder from myelin oligodendrocyte glycoprotein antibody-associated disease in optic neuritis.Frontiers in immunology · 2026Article
- Comparison of OCT Structural Parameters and OCTA-Measured Retinal Vessel Density and Peripapillary Choroidal Microvasculature in Glaucoma and Optic Neuritis From Multiple Sclerosis or Neuromyelitis Optica.Journal of ophthalmology · 2026Article
- Quantitative assessment of retinal microvasculature using optical coherence tomography angiography and correlation with visual acuity in leber's hereditary optic neuropathy.International ophthalmology · 2025Observational
- Serum GFAP and NFL as biomarkers for disease activity, severity and disability in NMOSD.Journal of neurology · 2025Article
- Optical coherence tomography angiography biomarkers in multiple sclerosis and neuromyelitis optica spectrum disorders: a systematic review.International journal of retina and vitreous · 2025Review
- Optical coherence tomography and angiography reveal early retinal alterations in pediatric-onset multiple sclerosis.European journal of pediatrics · 2025Article
- NMOSD and MOGAD: an evolving disease spectrum.Nature reviews. Neurology · 2024Review
- Retinal small vessel pathology is associated with disease burden in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Review
- The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography.Neurology(R) neuroimmunology & neuroinflammation · 2023Review
- Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) - revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis.Journal of neurology · 2023Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuromyelitis optica spectrum disorders (NMOSD) are neuroinflammatory diseases of the central nervous system. Patients suffer from recurring relapses and it is unclear whether relapse-independent disease activity occurs and whether this is of clinical relevance.
objectiveTo detect disease-specific alterations of the retinal vasculature that reflect disease activity during NMOSD.
methodsCross-sectional analysis of 16 patients with NMOSD, 21 patients with relapsing-remitting multiple sclerosis, and 21 healthy controls using retinal optical coherence tomography (OCT), optical coherence tomography angiography (OCT-A), measurement of glial fibrillary acidic protein (GFAP) serum levels, and assessment of visual acuity.
resultsPatients with NMOSD but not multiple sclerosis revealed lower foveal thickness (FT) (
conclusionSubclinical parafoveal retinal vessel loss might occur during NMOSD and might be linked to astrocyte damage and poor visual performance. OCT-A may be a tool to study subclinical disease activity during NMOSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.