Evidence map›Paper›PMID 34259578›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022

Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study.

Einar August Høgestøl, Samuele Ghezzo, Gro Owren Nygaard, Thomas Espeseth, Piotr Sowa, Mona K Beyer, Hanne Flinstad Harbo, Lars T Westlye, Hanneke E Hulst, Dag Alnæs

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In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Einar August Høgestøl"Department of Neurology, Neuroscience Research Unit, Multiple Sclerosis Research Group University of Oslo & Oslo University Hospital; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0001-8446-2111
Samuele GhezzoNORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway/Department of Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Gro Owren NygaardDepartment of Neurology, Neuroscience Research Unit, Multiple Sclerosis Research Group University of Oslo & Oslo University Hospital, Oslo, Norway.
Thomas EspesethDepartment of Psychology, University of Oslo, Oslo, Norway; Bjørknes College, Oslo, Norway.
Piotr SowaDivision of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Mona K BeyerInstitute of Clinical Medicine, University of Oslo, Oslo, Norway/Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Hanne Flinstad Harbo"Department of Neurology, Neuroscience Research Unit, Multiple Sclerosis Research Group University of Oslo & Oslo University Hospital; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Lars T WestlyeNORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway/Department of Psychology, University of Oslo, Oslo, Norway/KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.
Hanneke E HulstDepartment of Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands/Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.ORCID 0000-0002-5039-1359
Dag AlnæsNORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Bjørknes College, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrain functional connectivity (FC) in multiple sclerosis (MS) is abnormal compared to healthy controls (HCs). More longitudinal studies in MS are needed to evaluate whether FC stability is clinically relevant.

objectiveTo compare functional magnetic resonance imaging (fMRI)-based FC between MS and HC, and to determine the relationship between longitudinal FC changes and structural brain damage, cognitive performance and physical disability.

methodsT1-weighted MPRAGE and resting-state fMRI (1.5T) were acquired from 70 relapsing-remitting MS patients and 94 matched HC at baseline (mean months since diagnosis 14.0 ± 11) and from 60 MS patients after 5 years. Independent component analysis and network modelling were used to measure longitudinal FC stability and cross-sectional comparisons with HC. Linear mixed models, adjusted for age and sex, were used to calculate correlations.

resultsAt baseline, patients with MS showed FC abnormalities both within networks and in single connections compared to HC. Longitudinal analyses revealed functional stability and no significant relationships with clinical disability, cognitive performance, lesion or brain volume.

conclusionFC abnormalities occur already at the first decade of MS, yet we found no relevant clinical correlations for these network deviations. Future large-scale longitudinal fMRI studies across a range of MS subtypes and outcomes are required.

Indexed as

ConnectomeMultiple SclerosisBrainCross-Sectional StudiesFollow-Up StudiesHumansMagnetic Resonance Imagingcohort studiesconnectomefunctional neuroimaginglongitudinal studiesMultiple sclerosisneuroimagingneuropsychological tests

Identifiers

PMID34259578
PMCPMC8961247

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.