Evidence map›Paper›PMID 34259396›Full record

ArticleChemMedChem2021

Zap-Pano: a Photocaged Prodrug of the KDAC Inhibitor Panobinostat.

Kathrin S Troelsen, Ewen D D Calder, Anna Skwarska, Deborah Sneddon, Ester M Hammond, Stuart J Conway

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. ACS pharmacology & translational science · 2025
    Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kathrin S TroelsenDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.ORCID 0000-0002-8734-533X
Ewen D D CalderDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.ORCID 0000-0001-7201-8451
Anna SkwarskaDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, OX3 7DQ, UK.ORCID 0000-0002-0979-026X
Deborah SneddonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
Ester M HammondDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, OX3 7DQ, UK.ORCID 0000-0002-2335-3146
Stuart J ConwayDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.ORCID 0000-0002-5148-117X
University of Oxford · GBUniversity of Copenhagen · DK

Funding

EPSRC EP/S019901/1Lundbeck foundation R218-2016-1277Medical Research Council MR/N009460/1MRC MR/N009460/1
6 · The paper itself

Abstract

We report the synthesis and biological evaluation of a light-activated (caged) prodrug of the KDAC inhibitor panobinostat (Zap-Pano). We demonstrate that addition of the 4,5-dimethoxy-2-nitrobenzyl group to the hydroxamic acid oxygen results in an inactive prodrug. In two cancer cell lines we show that photolysis of this compound releases panobinostat and an unexpected carboxamide analogue of panobinostat. Photolysis of Zap-Pano causes an increase in H3K9Ac and H3K18Ac, consistent with KDAC inhibition, in an oesophageal cancer cell line (OE21). Irradiation of OE21 cells in the presence of Zap-Pano results in apoptotic cell death. This compound is a useful research tool, allowing spatial and temporal control over release of panobinostat.

Indexed as

Antineoplastic AgentsApoptosisCell DeathCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHistone Deacetylase InhibitorsHistone DeacetylasesHumansMolecular StructurePanobinostatProdrugsStructure-Activity RelationshipAntineoplastic AgentsHistone Deacetylase InhibitorsHistone DeacetylasesPanobinostatProdrugshypoxiaKDACPanobinostatprodrugs

Identifiers

PMID34259396
PMCPMC9291796
OpenAlexW3180859729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.