Evidence map›Paper›PMID 34259355›Full record

ArticleJournal of leukocyte biology2022

Macrophage inflammatory state influences susceptibility to lysosomal damage.

Amanda O Wong, Matangi Marthi, Amanda Haag, Irene A Owusu, Christiane E Wobus, Joel A Swanson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Lysosomal Repair in Health and Disease.Journal of cellular physiology · 2025
    Review
  2. Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Amanda O WongDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Matangi MarthiDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Amanda HaagDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Irene A OwusuDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Christiane E WobusDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Joel A SwansonDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
University of Michigan–Ann Arbor · USUniversity of Ghana · GH

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
The Regulation of MacropinocytosisR35GM131720 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, JOEL A · 2019 to 2023
$2.4M
Inducible Renitence in MacrophagesR01GM101189 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, JOEL A · 2013 to 2016
$1.2M
NIGMS NIH HHS R01 GM101189NIGMS NIH HHS R35 GM131720Wellcome Trust
6 · The paper itself

Abstract

Macrophages possess mechanisms for reinforcing the integrity of their endolysosomes against damage. This property, termed inducible renitence, was previously observed in murine macrophages stimulated with LPS, peptidoglycan, IFNγ, or TNFα, which suggested roles for renitence in macrophage resistance to infection by membrane-damaging pathogens. This study analyzed additional inducers of macrophage differentiation for their ability to increase resistance to lysosomal damage by membrane-damaging particles. Renitence was evident in macrophages activated with LPS plus IFNγ, PGE

Indexed as

LipopolysaccharidesTumor Necrosis Factor-alphaAnimalsLysosomesMacrophagesMiceMyeloid Differentiation Factor 88Toll-Like Receptor 4LipopolysaccharidesMyeloid Differentiation Factor 88Toll-Like Receptor 4Tumor Necrosis Factor-alphainducible renitencemacrophage activationTLRtype 1 IFN

Identifiers

PMID34259355
PMCPMC8758784
OpenAlexW3180004710

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.