Observational studyAnnals of medicine2021
Circulating white blood cells and lung function impairment: the observational studies and Mendelian randomization analysis.
Observational study in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Respiratory tract diseases and lung function in coke oven plant workers: a 50-year global systematic evaluation and meta-analysis.Respiratory research · 2026Pooled it
- Genetic evidence for causal effects of leukocyte counts on risk for rheumatoid arthritis.Scientific reports · 2023Pooled it
- Association between the Dietary Inflammatory Index and lung function in exacerbated chronic obstructive pulmonary disease: The mediating role of inflammatory indicators.Asia Pacific journal of clinical nutrition · 2026Article
- Relationship of subclinical lung injury to chronic airway inflammation in spinocerebellar ataxia type 3.Orphanet journal of rare diseases · 2026Article
- Inflammatory score, intrinsic capacity and the risk of new-onset chronic lung disease: a cohort study from the China Health and Retirement Longitudinal Study.Journal of thoracic disease · 2026Article
- Association of Blood Eosinophil Counts with Expiratory Airflow Limitation: A Multi-Ethnicity Observational Study.Journal of inflammation research · 2026Article
- CD14+ Monocytes Will Become a New Target for the Treatment of Osteoporosis: Based on Mendel Randomization, Clinical Analysis and Cell Experiment Verification.Journal of cellular and molecular medicine · 2026Article
- COVID-19, inflammatory cytokines, and digestive system cancers: a bidirectional Mendelian study and mediation analysis.Discover oncology · 2025Article
- Peripheral inflammation in spinocerebellar ataxia type 3: associations with genetic and clinical manifestations.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- The association between systemic inflammation, lung function and respiratory symptoms in the BOLD study in Northern Europe.Scientific reports · 2025Article
- Dietary Vitamin C Intake Affects Lung Function Through White Blood Cell.Food science & nutrition · 2025Article
- Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study.BMC pulmonary medicine · 2025Article
- The causal association between neutrophil counts and the risk of lung cancer: a Mendelian randomization study.Journal of Cancer · 2025Article
- Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model.Antioxidants (Basel, Switzerland) · 2024Article
- Co-exposure effects of urinary polycyclic aromatic hydrocarbons and metals on lung function: mediating role of systematic inflammation.BMC pulmonary medicine · 2024Article
- The impact of inflammatory cells on lung function in asthmatics in a cross sectional retrospect study.Heliyon · 2024Article
- Inverted U-Shaped relationship Between Systemic Immune-Inflammation Index and Pulmonary Function: A Large Population-Based Study in US Adults.International journal of chronic obstructive pulmonary disease · 2024Article
- COVID-19 susceptibility and severity for dyslipidemia: A mendelian randomization investigation.Heliyon · 2023Article
- Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease.Thorax · 2023Article
- Prediction value of neutrophil and eosinophil count at risk of COPD exacerbation.Annals of medicine · 2023Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCirculating white blood cell (WBC) counts have been related to lung function impairment, but causal relationship was not established. We aimed to evaluate independent effects and causal relationships of WBC subtypes with lung function.
methodsThe 19,159 participants from NHANES 2011-2012 (
resultsTotal WBC counts were negatively associated with lung function among three populations and their pooled analysis indicated that per 1 × 10
conclusionsWBC subtypes were independently associated with lower lung function except lymphocytes. Our findings suggest that circulating neutrophils may be causal factors in lung function impairment.KEY MESSAGESWhite blood cell (WBC) subtypes were negatively associated with lung function level except lymphocytes in the observational studies.Associations of WBC subtypes with lung function may be modified by sex and smoking.Mendelian randomization analysis shows that neutrophils may be causal factors in lung function impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.