ArticleExperimental biology and medicine (Maywood, N.J.)2021
Three-dimensional segmentation and depth-encoded visualization of choroidal vasculature using swept-source optical coherence tomography.
Article in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Interocular differences in choroidal thickness and circulation in anisomyopic adults and their association with myopia severity.Frontiers in medicine · 2025Article
- Advancements in Imaging and Therapeutic Options for Dry Age-Related Macular Degeneration and Geographic Atrophy.Ophthalmology and therapy · 2024Review
- Choroidal Vessel and Stromal Volumetric Analysis After Photodynamic Therapy or Focal Laser for Central Serous Chorioretinopathy.Translational vision science & technology · 2023Article
- Recent Advances in Imaging Polypoidal Choroidal Vasculopathy with Swept-Source Optical Coherence Tomography Angiography.Diagnostics (Basel, Switzerland) · 2023Review
- IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia.Investigative ophthalmology & visual science · 2023Review
- A 3D Analysis of Cleared Human Melanoma.Biomedicines · 2022Article
- Diagnosis of Choroidal Disease With Deep Learning-Based Image Enhancement and Volumetric Quantification of Optical Coherence Tomography.Translational vision science & technology · 2022Article
- Emerging imaging developments in experimental vision sciences and ophthalmology.Experimental biology and medicine (Maywood, N.J.) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The choroid provides nutritional support for the retinal pigment epithelium and photoreceptors. Choroidal dysfunction plays a major role in several of the most important causes of vision loss including age-related macular degeneration, myopic degeneration, and pachychoroid diseases such as central serous chorioretinopathy and polypoidal choroidal vasculopathy. We describe an imaging technique using depth-resolved swept-source optical coherence tomography (SS-OCT) that provides full-thickness three-dimensional (3D) visualization of choroidal anatomy including topographical features of individual vessels. Enrolled subjects with different clinical manifestations within the pachychoroid disease spectrum underwent 15 mm × 9 mm volume scans centered on the fovea. A fully automated method segmented the choroidal vessels using their hyporeflective lumens. Binarized choroidal vessels were rendered in a 3D viewer as a vascular network within a choroidal slab. The network of choroidal vessels was color depth-encoded with a reference to the Bruch's membrane segmentation. Topographical features of the choroidal vasculature were characterized and compared with choroidal imaging obtained with indocyanine green angiography (ICGA) from the same subject. The
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Registered trials
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