Evidence map›Paper›PMID 34259046›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Fetal growth, high altitude, and evolutionary adaptation: a new perspective.

Kathryn Wilsterman, Zachary A Cheviron

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  6. Adaptive structural and functional evolution of the placenta protects fetal growth in high-elevation deer mice.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kathryn WilstermanDivision of Biological Sciences, University of Montana, Missoula, Montana.ORCID 0000-0001-7262-9754
Zachary A ChevironDivision of Biological Sciences, University of Montana, Missoula, Montana.
University of Montana · US

Funding

Understanding the etiology of altitude-related obstetric complications through evolutionary adaptationR15HD103925 · NICHD · UNIVERSITY OF MONTANA · PI CHEVIRON, ZACHARY · 2020 to 2020
$441k
NICHD NIH HHS R15 HD103925
6 · The paper itself

Abstract

Residence at high altitude is consistently associated with low birthweight among placental mammals. This reduction in birthweight influences long-term health trajectories for both the offspring and mother. However, the physiological processes that contribute to fetal growth restriction at altitude are still poorly understood, and thus our ability to safely intervene remains limited. One approach to identify the factors that mitigate altitude-dependent fetal growth restriction is to study populations that are protected from fetal growth restriction through evolutionary adaptations (e.g., high altitude-adapted populations). Here, we examine human gestational physiology at high altitude from a novel evolutionary perspective that focuses on patterns of physiological plasticity, allowing us to identify

Indexed as

AltitudeBiological EvolutionAdaptation, PhysiologicalAnimalsFemaleFetal DevelopmentFetusHumansPlacentaPregnancygestationhypoxiaphysiological plasticitypregnancySGA

Identifiers

PMID34259046
PMCPMC8530763
OpenAlexW3181087638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.