SynthesisJournal of the American Heart Association2021
Predictors of Permanent Pacemaker Implantation in Patients Undergoing Transcatheter Aortic Valve Replacement - A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Transcatheter or Surgical Treatment of Patients With Aortic Stenosis at Low to Intermediate Risk: An Individual Participant Data Meta-Analysis.JAMA cardiology · 2025Pooled it
- Perioperative Risk Factors for Permanent Pacemaker Implantation After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Comparative outcomes of Myval versus contemporary transcatheter heart valves: a systematic review and meta-analysis.Cardiovascular intervention and therapeutics · 2025Pooled it
- Modifiable risk factors for permanent pacemaker after transcatheter aortic valve implantation: CONDUCT registry.Open heart · 2023Trial
- Extremely Late Complete AV Block After TAVR: ECG Clues and Correction With Left Bundle Branch Pacing.Pacing and clinical electrophysiology : PACE · 2026Article
- Transapical epicardial temporary pacemaker lead implantation in patients with transapical TAVI.Open heart · 2026Article
- Preprocedural CALLY Index As a Novel Predictor of Pacemaker Requirement After Transcatheter Aortic Valve Replacement.CJC open · 2026Article
- Current Trends and Future Challenges in Transcatheter Aortic Valve Implantation (TAVI): A Narrative Review.Journal of clinical medicine · 2026Review
- Permanent Pacemaker Implantation Following Transcatheter Aortic Valve Replacement: Incidence, Predictors, and Association With Reduced Ischemic Stroke Risk.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Review
- Children are Less Likely Than Adults to Develop Complete Heart Block Following TAVR.Pediatric cardiology · 2026Article
- Article
- Structural and Non-Structural Deterioration After Biological Aortic Valve Replacement: Long-Term Outcomes of 918 High-Risk Patients.Journal of cardiovascular development and disease · 2026Article
- A Clinical Risk Prediction Model for Identifying Patient Candidates for Same-day Discharge After Transcatheter Aortic Valve Replacement.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Impaired left atrial strain as a predictor of bradyarrhythmias and clinical outcomes following TAVI.The international journal of cardiovascular imaging · 2026Article
- Impact of Baseline Atrial Fibrillation on Conduction Disturbances After TAVR: Insights from a Large Cohort Study.Journal of clinical medicine · 2025Article
- Molecular Mechanisms of Cardiac Adaptation After Device Deployment.Journal of cardiovascular development and disease · 2025Review
- Isolated Rapid Deployment Aortic Valve Replacement in Patients with Aortic Stenosis: Single-Center Retrospective Study.Journal of cardiovascular development and disease · 2025Article
- Self-Expanding Transcatheter Aortic Valve Implantation in Patients with Severe Aortic Stenosis Undergoing Prosthetic Mitral Valve Replacement: A Single-Center Experience.Anatolian journal of cardiology · 2025Article
- Contemporary Management of the Aortic Valve-Narrative Review of an Evolving Landscape.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background As transcatheter aortic valve replacement (TAVR) technology expands to healthy and lower-risk populations, the burden and predictors of procedure-related complications including the need for permanent pacemaker (PPM) implantation needs to be identified. Methods and Results Digital databases were systematically searched to identify studies reporting the incidence of PPM implantation after TAVR. A random- and fixed-effects model was used to calculate unadjusted odds ratios (OR) for all predictors. A total of 78 studies, recruiting 31 261 patients were included in the final analysis. Overall, 6212 patients required a PPM, with a mean of 18.9% PPM per study and net rate ranging from 0.16% to 51%. The pooled estimates on a random-effects model indicated significantly higher odds of post-TAVR PPM implantation for men (OR, 1.16; 95% CI, 1.04-1.28); for patients with baseline mobitz type-1 second-degree atrioventricular block (OR, 3.13; 95% CI, 1.64-5.93), left anterior hemiblock (OR, 1.43; 95% CI, 1.09-1.86), bifascicular block (OR, 2.59; 95% CI, 1.52-4.42), right bundle-branch block (OR, 2.48; 95% CI, 2.17-2.83), and for periprocedural atriorventricular block (OR, 4.17; 95% CI, 2.69-6.46). The mechanically expandable valves had 1.44 (95% CI, 1.18-1.76), while self-expandable valves had 1.93 (95% CI, 1.42-2.63) fold higher odds of PPM requirement compared with self-expandable and balloon-expandable valves, respectively. Conclusions Male sex, baseline atrioventricular conduction delays, intraprocedural atrioventricular block, and use of mechanically expandable and self-expanding prosthesis served as positive predictors of PPM implantation in patients undergoing TAVR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.