Evidence map›Paper›PMID 34259042›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Influence of ischemia-reperfusion injury on endothelial function in men and women with similar serum estradiol concentrations.

Sophie Lalande, Holden W Hemingway, Caitlin P Jarrard, Amy M Moore, Albert H Olivencia-Yurvati, Rauchelle E Richey, Steven A Romero

Abstract readComparative Study
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sophie LalandeDepartment of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas.ORCID 0000-0001-9452-7206
Holden W HemingwayDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Caitlin P JarrardDepartment of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas.
Amy M MooreDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Albert H Olivencia-YurvatiDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Rauchelle E RicheyDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Steven A RomeroDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.ORCID 0000-0002-2014-7806

Funding

Chronic Lower Leg Heating for the Treatment of Hypertension in Older WomenR01AG059314 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI FU, QI, ROMERO, STEVEN A. · 2019 to 2023
$3.3M
NIA NIH HHS R01 AG059314
6 · The paper itself

Abstract

Prior data suggest that, relative to the early follicular phase, women in the late follicular phase are protected against endothelial ischemia-reperfusion (I/R) injury when estradiol concentrations are highest. In addition, endothelial I/R injury is consistently observed in men with naturally low endogenous estradiol concentrations that are similar to those of women in the early follicular phase. Therefore, the purpose of this study was to determine whether the vasodeleterious effect of I/R injury differs between women in the early follicular phase of the menstrual cycle and age-matched men. We tested the hypothesis that I/R injury would attenuate endothelium-dependent vasodilation to the same extent in women and age-matched men with similar circulating estradiol concentrations. Endothelium-dependent vasodilation was assessed via brachial artery flow-mediated dilation (duplex ultrasound) in young healthy men (

Indexed as

VasodilationAdultArmBrachial ArteryEndothelium, VascularEstradiolFemaleFollicular PhaseHumansMaleReperfusion InjurySex FactorsYoung AdultEstradiolendothelial functionflow-mediated dilationischemia-reperfusion injurysex differences

Identifiers

PMID34259042
PMCPMC8424541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.