Evidence map›Paper›PMID 34258889›Full record

ArticleObesity (Silver Spring, Md.)2021

Changes in mood and health-related quality of life in Look AHEAD 6 years after termination of the lifestyle intervention.

Look AHEAD Research Group, Thomas A Wadden, Ariana M Chao, Harelda Anderson, Kirsten Annis, Karen Atkinson, Paula Bolin, Phillip Brantley, Jeanne M Clark, Mace Coday and 31 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Late-life disability following the action for health in diabetes (Look AHEAD) trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Trial
  2. Trial
  3. Obesity and healthy aging: fat, muscle, and bone trade-offs in an era of potent weight-loss pharmacotherapy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Look AHEAD Research Group
Thomas A WaddenDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0438-4609
Ariana M ChaoDepartment of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-5633-8973
Harelda AndersonSouthwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, and Shiprock, New Mexico, USA.
Kirsten AnnisDepartment of Psychiatry, the Miriam Hospital, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Karen AtkinsonDivision of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.
Paula BolinSouthwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, and Shiprock, New Mexico, USA.
Phillip BrantleyPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Jeanne M ClarkDivision of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Mace CodayDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Gareth DuttonDepartment of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
John P ForeytDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Edward W GreggDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Helen P HazudaDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
James O HillDepartment of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
Van S HubbardDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
John M JakicicDepartment of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6800-9368
Robert W JefferyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.
Karen C JohnsonDepartments of Preventive Medicine and Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID 0000-0002-3493-4077
Steven E KahnDivision of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.
William C KnowlerSouthwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, and Shiprock, New Mexico, USA.
Mary KorytkowskiDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cora E LewisDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-2301-5796
Blandine LaferrèreDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Roeland J MiddelbeekJoslin Diabetes Center, Boston, Massachusetts, USA.
Medha N MunshiJoslin Diabetes Center, Boston, Massachusetts, USA.
David M NathanDiabetes Center, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts, USA.
Rebecca H NeibergDepartment of Biostatistics and Data Science, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
Scott J PillaDivision of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Anne PetersDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Xavier Pi-SunyerDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Jack W RejeskiDepartment of Health and Exercise Sciences, Wake Forest University, Winston-Salem, North Carolina, USA.ORCID 0000-0003-2281-4649
Bruce RedmonDepartment of Medicine, University of Minnesota Medical School, Twin Cities, Minneapolis, Minnesota, USA.
Tiffany StewartPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Elizabeth VaughanDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-9565-0134
Lynne E WagenknechtDepartment of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Michael P WalkupDepartment of Biostatistics and Data Science, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
Rena R WingDepartment of Psychiatry, the Miriam Hospital, Alpert Medical School, Brown University, Providence, Rhode Island, USA.ORCID 0000-0002-0918-8252
Holly WyattDepartment of Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.
Susan Z YanovskiDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Ping ZhangCenters for Disease Control and Prevention, DDT Health Economics Workgroup Atlanta, Atlanta, Georgia, USA.

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
Look AHEAD: Action for Health in DiabetesU01DK057136 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW, WAGENKNECHT, LYNNE E · 1999 to 2020
$54.9M
ZOPOLRESTAT PHARMACOKINETICS IN DIABETICS WITH VARYING RENAL FUNCTIONM01RR000051 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KOSMISKI, LISA A. · 1985 to 2008
$52.6M
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 1985 to 2008
$37.4M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
ZOLEDRONATE VS AREDIA IN MULTIPLE MYELOMA/BREAST CANCER W /BONE DISORDERSM01RR001346 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FERRER, ROBERT L · 1985 to 2008
$23.1M
SHOW PROJECTU01DK057154 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NATHAN, DAVID M · 1999 to 2020
$23.1M
Look AHEAD: Action for Health DiabetesU01DK057178 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI LAFERRERE, BLANDINE B · 1999 to 2020
$21.2M
ZINC THERAPY FOR SCLERODERMA--PHASE I STUDYM01RR002719 · NCRR · JOHNS HOPKINS UNIVERSITY · PI EARLEY, CHRISTOPHER J · 1986 to 2007
$20.2M
NCRR NIH HHS M01 RR000051NCRR NIH HHS M01 RR000056NCRR NIH HHS M01 RR001066NCRR NIH HHS M01 RR001346NCRR NIH HHS M01 RR002719NCRR NIH HHS UL1 RR024153NCRR NIH HHS UL1 RR025758NIA NIH HHS AG058571NIA NIH HHS R01 AG058571NIA NIH HHS U01 AG073697NIDDK NIH HHS DK56990NIDDK NIH HHS DK56992NIDDK NIH HHS DK57002NIDDK NIH HHS DK57008NIDDK NIH HHS DK57078NIDDK NIH HHS DK57131NIDDK NIH HHS DK57135NIDDK NIH HHS DK57136NIDDK NIH HHS DK57149NIDDK NIH HHS DK57151NIDDK NIH HHS DK57154NIDDK NIH HHS DK57171NIDDK NIH HHS DK57177NIDDK NIH HHS DK57178NIDDK NIH HHS DK57182NIDDK NIH HHS DK57219NIDDK NIH HHS K23 DK110341NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK046204NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK111022NIDDK NIH HHS U01 DK056990NIDDK NIH HHS U01 DK056992NIDDK NIH HHS U01 DK057002NIDDK NIH HHS U01 DK057008NIDDK NIH HHS U01 DK057078NIDDK NIH HHS U01 DK057131NIDDK NIH HHS U01 DK057135NIDDK NIH HHS U01 DK057136NIDDK NIH HHS U01 DK057149NIDDK NIH HHS U01 DK057151NIDDK NIH HHS U01 DK057154NIDDK NIH HHS U01 DK057171NIDDK NIH HHS U01 DK057177NIDDK NIH HHS U01 DK057178NIDDK NIH HHS U01 DK057182NIDDK NIH HHS U01 DK057219
6 · The paper itself

Abstract

objectiveThe Action for Health in Diabetes (Look AHEAD) study previously reported that intensive lifestyle intervention (ILI) reduced incident depressive symptoms and improved health-related quality of life (HRQOL) over nearly 10 years of intervention compared with a control group (the diabetes support and education group [DSE]) in participants with type 2 diabetes and overweight or obesity. The present study compared incident depressive symptoms and changes in HRQOL in these groups for an additional 6 years following termination of the ILI in September 2012.

methodsA total of 1,945 ILI participants and 1,900 DSE participants completed at least one of four planned postintervention assessments at which weight, mood (via the Patient Health Questionnaire-9), antidepressant medication use, and HRQOL (via the Medical Outcomes Scale, Short Form-36) were measured.

resultsILI participants and DSE participants lost 3.1 (0.3) and 3.8 (0.3) kg [represented as mean (SE); p = 0.10], respectively, during the 6-year postintervention follow-up. No significant differences were observed between groups during this time in incident mild or greater symptoms of depression, antidepressant medication use, or in changes on the physical component summary or mental component summary scores of the Short Form-36. In both groups, mental component summary scores were higher than physical component summary scores.

conclusionsPrior participation in the ILI, compared with the DSE group, did not appear to improve subsequent mood or HRQOL during 6 years of postintervention follow-up.

Indexed as

Diabetes Mellitus, Type 2Quality of LifeHumansLife StyleOverweightWeight Loss

Identifiers

PMID34258889
PMCPMC8903054

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.