Trial reportThe American journal of clinical nutrition2021
Impact of low-fat and full-fat dairy foods on fasting lipid profile and blood pressure: exploratory endpoints of a randomized controlled trial.
Trial report in The American journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02663544 (The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Effects of Dairy Intake on Markers of Cardiometabolic Health in Adults: A Systematic Review with Network Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- The Effect of Three Daily Servings of Full-Fat Dairy for 12 Weeks on Body Weight, Body Composition, Energy Metabolism, Blood Lipids, and Dietary Intake of Adults with Overweight and Obesity.The Journal of nutrition · 2026Trial
- Full-fat yogurt compared with non-fat yogurt reduces blood triacylglycerol concentrations and lowers the triacylglycerol content in specific lipoprotein subclasses in adults with prediabetes: an exploratory analysis of a randomized-controlled trial.Lipids in health and disease · 2025Trial
- Dietary Ewe's Yogurt Intake Selectively Modulates HDL Subfractions Without Altering LDL Particle Size in Women: A Six-Week Intervention Study.Nutrients · 2026Article
- Culturally acceptable fermented grain may improve gut health in South African postpartum mothers in a randomised trial.The British journal of nutrition · 2026Article
- Beverage patterns, blood pressure, and proteinuria among West Africans with chronic kidney disease: a cross-sectional analysis of the diet, CKD, and apolipoprotein L1 study.Frontiers in nutrition · 2026Article
- Dairy Intake and Coronary Artery Calcification: The Coronary Artery Risk Development in Young Adults (CARDIA) Prospective Cohort Study.The Journal of nutrition · 2025Article
- Review
- The relationship between the intake of fruits, vegetables, and dairy products and dyslipidemia in STEPs study.BMC research notes · 2025Article
- Rising burden of subarachnoid hemorrhage linked to high systolic blood pressure among young and middle-aged populations: temporal trends and global implication.Frontiers in human neuroscience · 2025Article
- The association of dietary pattern with the risk of common chronic diseases in Shandong Province, China: a cross-sectional study.Frontiers in public health · 2025Article
- Association between dietary patterns and the risk of all-cause mortality among old adults with obstructive sleep apnea.BMC geriatrics · 2024Article
- Diet-related inflammation is positively associated with atherogenic indices.Scientific reports · 2024Observational
- The relationship between fermented and nonfermented dairy products consumption and hypertension among premature coronary artery disease patients: Iran premature coronary artery disease study.Food science & nutrition · 2024Article
- Specific dairy foods and risk of frailty in older women: a prospective cohort study.BMC medicine · 2024Article
- Healthy Effects of Milk and Dairy Product Consumption in the Mediterranean Area and Japan.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Whole-Milk Dairy Foods: Biological Mechanisms Underlying Beneficial Effects on Risk Markers for Cardiometabolic Health.Advances in nutrition (Bethesda, Md.) · 2023Review
- The association between dietary quality scores with C-reactive protein and novel biomarkers of inflammation platelet-activating factor and lipoprotein-associated phospholipase A2: a cross-sectional study.Nutrition & metabolism · 2023Article
- Review
- Intake of Low Glycaemic Index Foods but Not Probiotics Is Associated with Atherosclerosis Risk in Women with Polycystic Ovary Syndrome.Life (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDietary guidelines traditionally recommend low-fat dairy because dairy's high saturated fat content is thought to promote cardiovascular disease (CVD). However, emerging evidence indicates that dairy fat may not negatively impact CVD risk factors when consumed in foods with a complex matrix.
objectiveThe aim was to compare the effects of diets limited in dairy or rich in either low-fat or full-fat dairy on CVD risk factors.
methodsIn this randomized controlled trial, 72 participants with metabolic syndrome completed a 4-wk run-in period, limiting their dairy intake to ≤3 servings/wk of nonfat milk. Participants were then randomly assigned to 1 of 3 diets, either continuing the limited-dairy diet or switching to a diet containing 3.3 servings/d of either low-fat or full-fat milk, yogurt, and cheese for 12 wk. Exploratory outcome measures included changes in the fasting lipid profile and blood pressure.
resultsIn the per-protocol analysis (n = 66), there was no intervention effect on fasting serum total, LDL, and HDL cholesterol; triglycerides; free fatty acids; or cholesterol content in 38 isolated plasma lipoprotein fractions (P > 0.1 for all variables in repeated-measures ANOVA). There was also no intervention effect on diastolic blood pressure, but a significant intervention effect for systolic blood pressure (P = 0.048), with a trend for a decrease in the low-fat dairy diet (-1.6 ± 8.6 mm Hg) compared with the limited-dairy diet (+2.5 ± 8.2 mm Hg) in post hoc testing. Intent-to-treat results were consistent for all endpoints, with the exception that systolic blood pressure became nonsignificant (P = 0.08).
conclusionsIn men and women with metabolic syndrome, a diet rich in full-fat dairy had no effects on fasting lipid profile or blood pressure compared with diets limited in dairy or rich in low-fat dairy. Therefore, dairy fat, when consumed as part of complex whole foods, does not adversely impact these classic CVD risk factors. This trial was registered at clinicaltrials.gov as NCT02663544.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.