Evidence map›Paper›PMID 34258602›Full record

ArticleBrain, behavior, & immunity - health2020

Gender differences in the link between depressive symptoms and

Erik L Knight, Marzieh Majd, Jennifer E Graham-Engeland, Joshua M Smyth, Martin J Sliwinski, Christopher G Engeland

Open access · goldAbstract read
In one paragraph

Article in Brain, behavior, & immunity - health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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  6. Moving toward affective immunology: Legacy and future directions.Comprehensive psychoneuroendocrinology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Erik L KnightCenter for Healthy Aging, The Pennsylvania State University.
Marzieh MajdDepartment of Biobehavioral Health, The Pennsylvania State University.
Jennifer E Graham-EngelandCenter for Healthy Aging, The Pennsylvania State University.
Joshua M SmythCenter for Healthy Aging, The Pennsylvania State University.
Martin J SliwinskiCenter for Healthy Aging, The Pennsylvania State University.
Christopher G EngelandCenter for Healthy Aging, The Pennsylvania State University.
Pennsylvania State University · USPenn State Milton S. Hershey Medical Center · US

Funding

Psychosocial Determinants and Biological Pathway to Healthy Aging (Pathways)T32AG049676 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LYNN M. MARTIRE · 2016 to 2026
$3.9M
Stress, Unconstructive Repetitive Thought and Cognitive AgingR01AG039409 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI SLIWINSKI, MARTIN J · 2011 to 2015
$2.5M
Inflammatory Mediators of Stress and Cognitive AgingR01AG042595 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI ENGELAND, CHRISTOPHER G, GRAHAM-ENGELAND, JENNIFER ELISE · 2012 to 2016
$1.6M
NIA NIH HHS R01 AG039409NIA NIH HHS R01 AG042595NIA NIH HHS T32 AG049676
6 · The paper itself

Abstract

Depressive symptoms are often linked with higher inflammation and inflammatory responses, although these associations are not always consistent. In a recent study (N=160, 25-65 years, 67% women), our group reported gender differences relevant to this association: In men higher depressive symptoms were related to heightened ex vivo inflammatory responses to lipopolysaccharide (LPS), whereas in women higher depressive symptoms were related to attenuated inflammatory responses. In the present manuscript, we investigate markers of endotoxemia - i.e., markers of the presence of endotoxin in the blood, presumably due to bacterial translocation from the gut - as factors that elicit gender-dependent immune responses that may be associated with links between depressive symptoms and inflammation. We examined

Indexed as

CD14cytokinesdepressionendotoxemiagenderinflammationLBPsex

Identifiers

PMID34258602
PMCPMC8274590
OpenAlexW2998911768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.