ArticleEClinicalMedicine2021
Systemic acidemia impairs cardiac function in critically Ill patients.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- AKI as a systemic syndrome and its impact on other organ systems.Critical care (London, England) · 2026Review
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- Alterations of acid-base- and electrolyte status immediately following electroconvulsive therapy.Journal of neural transmission (Vienna, Austria : 1996) · 2026Observational
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- Effect modification by chronic obstructive pulmonary disease, anion gap, and serum creatinine on the association between invasive mechanical ventilation and 28-day mortality in intensive care unit sepsis patients: a retrospective cohort study.Frontiers in medicine · 2026Article
- Integrative analysis and imputation of multiple data streams via deep Gaussian processes.Bioinformatics advances · 2026Article
- CaBiomolecules · 2025Review
- Lung recruitment maneuver improves right and left ventricular function in patients with acute respiratory distress syndrome.BMC pulmonary medicine · 2025Article
- The "SOOTEST-ICU" bundle for optimizing cerebral hypoxia and reperfusion to minimize brain injury after resuscitation from cardiac arrest.World journal of emergency medicine · 2025Article
- Article
- Echocardiography in Cardiac Arrest: Incremental Diagnostic and Prognostic Role during Resuscitation Care.Diagnostics (Basel, Switzerland) · 2024Review
- A Contemporary Review of Blood Transfusion in Critically Ill Patients.Medicina (Kaunas, Lithuania) · 2024Review
- Metformin-associated lactic acidosis: A mini review of pathophysiology, diagnosis and management in critically ill patients.World journal of diabetes · 2024Review
- Point-of-Care Ultrasound for the Diagnosis of Congestive Kidney Due to Severe Acidemia: A Case Report.Cureus · 2024Article
- Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report.Journal of medical case reports · 2023Article
- Preoperative arterial lactate and outcome after surgery for type A aortic dissection: The ERTAAD multicenter study.Heliyon · 2023Article
- The Vasopressin Loading for Refractory septic shock (VALOR) study: a prospective observational study.Critical care (London, England) · 2023Observational
- The Molecular Mechanism and Therapeutic Strategy of Cardiorenal Syndrome Type 3.Reviews in cardiovascular medicine · 2023Review
- Heart during acidosis: Etiology and early detection of cardiac dysfunction.EClinicalMedicine · 2021Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcidemia, is associated with reduced cardiac function in animals, but no studies showing an effect of acidemia on cardiac function in humans are reported. In the present study, we examined the effect of acidemia on cardiac function assessed with transpulmonary thermodilution technique with integrated pulse contour analysis (Pulse Contour Cardiac Output, PiCCO™) in a large cohort of critically ill patients.
methodsThis was a prospective multicenter observational cross-sectional study of 297 patients from 6 intensive care units in London, England selected from all patients admitted consecutively between May 2018 and March 2019. Measurements of lowest plasma pH and concurrent assessment of cardiac function were obtained.
findingsThere was a significant difference between two pH categories (pH ≤ 7.28 vs. pH > 7.28) for the following variables of cardiac function: SVI (difference in means 32.7; 95% CI: 21 to 45 mL/m2;
interpretationAcidemia is associated with impaired cardiac function in seriously ill patients hospitalized in the intensive care unit supporting the potential value of early diagnosis and improvement of arterial pH in these patients.
fundingThe study was partially supported by unrestricted funds from the UCLA School of Medicine.
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