Evidence map›Paper›PMID 34258522›Full record

ArticleFASEB bioAdvances2021

In search of alternatively spliced alpha-Klotho Kl1 protein in mouse brain.

Liping Li, Johanne Pastor, Jianning Zhang, Taylor Davidson, Ming-Chang Hu, Orson W Moe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB bioAdvances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Constitutive transgenic α-Klotho overexpression enhances resilience to and recovery from murine acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Liping LiCharles and Jane Pak Center for Mineral Metabolism and Clinical Research Dallas TX USA.
Johanne PastorCharles and Jane Pak Center for Mineral Metabolism and Clinical Research Dallas TX USA.
Jianning ZhangDivision of Nephrology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX USA.
Taylor DavidsonCharles and Jane Pak Center for Mineral Metabolism and Clinical Research Dallas TX USA.
Ming-Chang HuCharles and Jane Pak Center for Mineral Metabolism and Clinical Research Dallas TX USA.ORCID https://orcid.org/0000-0002-3235-8301
Orson W MoeCharles and Jane Pak Center for Mineral Metabolism and Clinical Research Dallas TX USA.
Center for Clinical Research (United States) · USThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alpha-Klotho is a multi-functional protein essential for maintenance of a myriad of cell functions. αKlotho is a single transmembrane protein with a large extracellular segment consisting of two domains (termed Kl1 and Kl2) which is shed into the extracellular fluid by proteolytic cleavage to furnish circulating soluble αKlotho. Based on cDNA sequence, an alternatively spliced mRNA is predicted to translate to a putative soluble αKlotho protein in mouse and human with only the Kl1 domain that represents a "spliced αKlotho Kl1" (spKl1) and is released from the cell without membrane targeting or cleavage. The existence of this protein remains

Indexed as

alternative transcriptbrainKlothoprotein expression

Identifiers

PMID34258522
PMCPMC8255843
OpenAlexW3161135712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.