Evidence map›Paper›PMID 34258496›Full record

ArticleAPL bioengineering2021

Editorial: Understanding molecular interactions that underpin vascular mechanobiology.

Adam J Engler, Yingxiao Wang

Open access · goldAbstract readEditorial
In one paragraph

Article in APL bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adam J EnglerDepartment of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, California 92093, USA.ORCID https://orcid.org/0000-0003-1642-5380
Yingxiao WangDepartment of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, California 92093, USA.ORCID https://orcid.org/0000-0003-0265-326X
University of California San Diego · US

Funding

Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under FlowsR01HL121365 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIEN, SHU, WANG, YINGXIAO · 2014 to 2025
$7.5M
Mechanogenetics: An Integrated Approach to Aging in Muscle DysfunctionR01AG045428 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2013 to 2022
$3.4M
Mechanogenetics: An Integrated Approach to Aging in Muscle DysfunctionRF1AG045428 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2025 to 2025
$1.8M
NHLBI NIH HHS R01 HL121365NIA NIH HHS R01 AG045428NIA NIH HHS RF1 AG045428
6 · The paper itself

Abstract

Cells are exposed to a variety of mechanical forces in their daily lives, especially endothelial cells that are stretched from vessel distention and are exposed to hemodynamic shear stress from a blood flow. Exposure to excessive forces can induce a disease, but the molecular details on how these cells perceive forces, transduce them into biochemical signals and genetic events, i.e., mechanotransduction, and integrate them into physiological or pathological changes remain unclear. However, seminal studies in endothelial cells over the past several decades have begun to elucidate some of these signals. These studies have been highlighted in

Identifiers

PMID34258496
PMCPMC8253597
OpenAlexW3175958159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.