Evidence map›Paper›PMID 34258479›Full record

ArticleClinical neurophysiology practice2021

Occurrence of hyperventilation-induced high amplitude rhythmic slowing with altered awareness after successful treatment of typical absence seizures and a network hypothesis.

Simone Mattozzi, Caterina Cerminara, Maria A Sotgiu, Alessandra Carta, Antonella Coniglio, Denis Roberto, Delia M Simula, Gian Luca Pruneddu, Silvia Dell'Avvento, S Sonia Muzzu and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Simone MattozziSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
Caterina CerminaraDepartment of Neurosciences, Pediatric Neurology Unit (PNU), Tor Vergata University of Rome, Italy.
Maria A SotgiuDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Alessandra CartaSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
Antonella ConiglioDepartment of Neurosciences, Pediatric Neurology Unit (PNU), Tor Vergata University of Rome, Italy.
Denis RobertoDepartment of Neurosciences, Pediatric Neurology Unit (PNU), Tor Vergata University of Rome, Italy.
Delia M SimulaSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
Gian Luca PrunedduSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
Silvia Dell'AvventoSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
S Sonia MuzzuSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
Maria FaddaSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
Giovanni M LuzzuSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
Stefano SotgiuSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
Susanna CasellatoSection of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
University of Sassari · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTypical absence seizures (AS) are epileptic phenomena typically appearing in children 4-15 years of age and can be elicited by hyperventilation (HV). Hyperventilation-induced high-amplitude rhythmic slowing (HIHARS) represents a paraphysiological response during HV and may manifest with alteration of awareness (HIHARSAA). To date, HIHARSAA has mostly been described in patients without epilepsy.

aimTo describe five patients with treatment-responsive typical AS who, after becoming seizure free, presented with HIHARSAA.

methodsBy using video-electroencephalographic recording (Video-EEG), we describe differential clinical characteristics and ictal electrophysiological patterns of both typical AS and HIHARSAA.

resultsWe demonstrate that when HIHARSAA occurs in patients with typical AS there is a temporal window between the two phenomena. This suggests that the presence of typical AS precludes the appearance of HIHARSAA.

conclusionsWe hypothesize that alkalosis and dysfunction of the same neural network are involved in both typical AS and HIHARSAA and that their distinct electroclinic manifestations are due to the involvement of different ion channels. SIGNIFICANCE: A better understanding of the characteristics of typical AS and HIHARSAA and of the role of alkalosis in both, can help avoiding misdiagnosis and identifying more suitable therapies for typical AS.

Indexed as

AlkalosisHIHARSHyperventilationLoss of awarenessTypical absence

Identifiers

PMID34258479
PMCPMC8255168
OpenAlexW3166747851

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.