Evidence map›Paper›PMID 34258403›Full record

ArticlePhysics and imaging in radiation oncology2021

Registration of histopathology to magnetic resonance imaging of prostate cancer.

Kristina Sandgren, Erik Nilsson, Angsana Keeratijarut Lindberg, Sara Strandberg, Lennart Blomqvist, Anders Bergh, Bengt Friedrich, Jan Axelsson, Margareta Ögren, Mattias Ögren and 6 more

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kristina SandgrenDepartment of Radiation Sciences, Radiophysics, Umea University, Sweden.
Erik NilssonDepartment of Radiation Sciences, Radiophysics, Umea University, Sweden.
Angsana Keeratijarut LindbergDepartment of Radiation Sciences, Radiophysics, Umea University, Sweden.
Sara StrandbergDepartment of Radiation Sciences, Diagnostic Radiology, Umea University, Sweden.
Lennart BlomqvistDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Anders BerghDepartment of Medical Biosciences, Pathology, Umea University, Sweden.
Bengt FriedrichDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Sweden.
Jan AxelssonDepartment of Radiation Sciences, Radiophysics, Umea University, Sweden.
Margareta ÖgrenDepartment of Radiation Sciences, Diagnostic Radiology, Umea University, Sweden.
Mattias ÖgrenDepartment of Radiation Sciences, Diagnostic Radiology, Umea University, Sweden.
Anders WidmarkDepartment of Radiation Sciences, Oncology, Umea University, Sweden.
Camilla Thellenberg KarlssonDepartment of Radiation Sciences, Oncology, Umea University, Sweden.
Karin SöderkvistDepartment of Radiation Sciences, Oncology, Umea University, Sweden.
Katrine RiklundDepartment of Radiation Sciences, Diagnostic Radiology, Umea University, Sweden.
Joakim JonssonDepartment of Radiation Sciences, Radiophysics, Umea University, Sweden.
Tufve NyholmDepartment of Radiation Sciences, Radiophysics, Umea University, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe diagnostic accuracy of new imaging techniques requires validation, preferably by histopathological verification. The aim of this study was to develop and present a registration procedure between histopathology and MATERIALS AND

methodsFor twenty-five prostate cancer patients, planned for radical prostatectomy, a 3D-printed prostate mold based on

resultsEighty-four landmarks were identified, located in the urethra (62%), prostatic cysts (33%), and the ejaculatory ducts (5%). The median number of landmarks was 3 per patient. We showed a median in-plane error of 1.8 mm before and 1.7 mm after the contour-correcting deformable registration. In patients with extraprostatic margins, the median in-plane error improved from 2.1 mm to 1.8 mm after the contour-correcting deformable registration.

conclusionsOur registration procedure accurately registers histopathology to

Indexed as

Histopathology correlationImage registrationPET/MRIProstate cancer

Identifiers

PMID34258403
PMCPMC8254194

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.