ArticlePhysics and imaging in radiation oncology2021
Empirical quenching correction in radiochromic silicone-based three-dimensional dosimetry of spot-scanning proton therapy.
Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Suitability of Polyacrylamide-Based Dosimetric Gel for Proton and Carbon Ion Beam Geometric Characterization.Gels (Basel, Switzerland) · 2025Article
- Motion-induced dose perturbations in photon radiotherapy and proton therapy measured by deformable liver-shaped 3D dosimeters in an anthropomorphic phantom.Physics and imaging in radiation oncology · 2024Article
- Linear energy transfer-independent calibration of radiochromic film for carbon-ion beams.Physics and imaging in radiation oncology · 2022Article
- Optically stimulated luminescence in state-of-the-art LYSO:Ce scintillators enables high spatial resolution 3D dose imaging.Scientific reports · 2022Article
- Dose-response of deformable radiochromic dosimeters for spot scanning proton therapy.Physics and imaging in radiation oncology · 2020Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThree-dimensional dosimetry of proton therapy (PT) with chemical dosimeters is challenged by signal quenching, which is a lower dose-response in regions with high ionization density due to high linear-energy-transfer (LET) and dose-rate. This study aimed to assess the viability of an empirical correction model for 3D radiochromic silicone-based dosimeters irradiated with spot-scanning PT, by parametrizing its LET and dose-rate dependency. MATERIALS AND
methodsTen cylindrical radiochromic dosimeters (Ø50 and Ø75 mm) were produced in-house, and irradiated with different spot-scanning proton beam configurations and machine-set dose rates ranging from 56 to 145 Gy/min. Beams with incident energies of 75, 95 and 120 MeV, a spread-out Bragg peak and a plan optimized to an irregular target volume were included. Five of the dosimeters, irradiated with 120 MeV beams, were used to estimate the quenching correction factors. Monte Carlo simulations were used to obtain dose and dose-averaged-LET (LET
resultsGamma-pass-rates of the corrected measurements were >94% using a 3%-3 mm gamma analysis and >88% using 2%-2 mm, with a dose deviation of <5.6 ± 1.8%. Larger dosimeters showed a 20% systematic increase in dose-response, but the same quenching in signal when compared to the smaller dosimeters.
conclusionThe quenching correction model was valid for different dosimeter sizes to obtain relative dosimetric maps of complex dose distributions in PT.
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