ArticleInternational journal of cardiology. Heart & vasculature2021
Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease.
Article in International journal of cardiology. Heart & vasculature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01853527 (Myocardial Ischemia in Non-obstructive Coronary Artery Disease), which is not on this map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Myocardial Ischemia in Non-obstructive Coronary Artery Disease
Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Comparison of risk profiles of participants in the Women's IschemiA TRial to Reduce events In non-ObstRuctive CAD (WARRIOR) trial, using Coronary Computed Tomography Angiography vs Invasive Coronary Angiography.Progress in cardiovascular diseasesTrial
- Artificial intelligence-guided quantitative coronary CT assessment to rule-in or rule-out myocardial ischaemia.European heart journal. Cardiovascular Imaging · 2026Article
- Delaying cardiac aging: potential mechanisms centered on PANoptosis and targeted intervention strategies.Frontiers in cardiovascular medicine · 2026Review
- Coronary Computed Tomography Angiography Atherosclerotic Plaque Volume as A Predictor of Myocardial Blood Flow Impairment in Non-Obstructive Coronary Artery Disease.Reviews in cardiovascular medicine · 2025Article
- Prognostic Implication of Computational Angiography-Derived Fractional Flow Reserve in Patients With Nonobstructive Coronary Artery Disease.Journal of the American Heart Association · 2025Article
- Carotid calcifications in panoramic radiographs can predict vascular risk.Dento maxillo facial radiology · 2025Article
- Factors affecting the performance of a novel artificial intelligence-based coronary computed tomography-derived ischaemia algorithm.European heart journal. Imaging methods and practice · 2024Article
- Patient-Specific Numerical Simulations of Coronary Artery Hemodynamics and Biomechanics: A Pathway to Clinical Use.Cardiovascular engineering and technology · 2024Review
- Comparison of Coronary Artery Calcium and Quantitative Coronary Plaque in Predicting Obstructive Coronary Artery Disease: Subgroup Analysis of the CLARIFY Study.Heart international · 2024Article
- Epicardial adipose tissue volume, plaque vulnerability and myocardial ischemia in non-obstructive coronary artery disease.International journal of cardiology. Heart & vasculature · 2023Article
- Long-Term Clinical Impact of Patients with Multi-Vessel Non-Obstructive Coronary Artery Disease.Life (Basel, Switzerland) · 2023Article
- Association between coronary plaque volume and myocardial ischemia detected by dynamic perfusion CT imaging.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimWhether the total coronary atherosclerotic plaque burden is independently associated with myocardial ischemia in non-obstructive coronary artery disease (CAD) is not well established. We aimed to test the association of total plaque burden quantified by coronary computed tomography angiography (CCTA) with myocardial ischemia in patients with chronic coronary syndrome and non-obstructive CAD.
methodsWe included 125 patients (age 62 ± 9 years, 58% women) with chronic coronary syndrome and non-obstructive CAD (stenosis < 50%) by CCTA, who were grouped according to presence or absence of myocardial ischemia by myocardial contrast stress echocardiography. Total plaque burden was quantified by CCTA as the total plaque volume in the main coronary arteries, and positive remodelling was defined as remodelling index > 1.10.
resultsPatients with myocardial ischemia (n = 66) had higher total plaque burden (847 ± 245 mm
conclusionTotal coronary artery plaque burden by CCTA was independently associated with myocardial ischemia in patients with non-obstructive CAD. Whether plaque quantification is useful for clinical management of patients with non-obstructive CAD should be tested in prospective studies.ClinicalTrials.gov: Identifier NCT01853527.
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