ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease.
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Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
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- 2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy.Neurobiology of disease · 2025Review
- Portable, low-field magnetic resonance imaging for evaluation of Alzheimer's disease.Nature communications · 2024Article
- Influence of intergenerational social mobility on brain structure and global cognition: findings from the Whitehall II study across 20 years.Age and ageing · 2024Article
- Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients.Neurobiology of aging · 2024Article
- Is Alzheimer disease a disease?Nature reviews. Neurology · 2024Review
- Associations of dietary patterns and longitudinal brain-volume change in Japanese community-dwelling adults: results from the national institute for longevity sciences-longitudinal study of aging.Nutrition journal · 2024Article
- Precision brain morphometry using cluster scanning.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Brain morphometry in older adults with and without dementia using extremely rapid structural scans.NeuroImage · 2023Article
- Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Detecting short-interval longitudinal cortical atrophy in neurodegenerative dementias via cluster scanning: A proof of concept.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
43 authors at 20 institutions in 5 countries.
Ophir KeretGlobal Brain Health Institute University of California San Francisco California USA.
Adam M StaffaroniDepartment of Neurology, Memory and Aging Center University of California San Francisco California USA.
John M RingmanAlzheimer's Disease Research Center, Keck School of Medicine University of Southern California Los Angeles California USA.
Yann CobigoDepartment of Neurology, Memory and Aging Center University of California San Francisco California USA.
Sheng-Yang M GohDepartment of Neurology, Memory and Aging Center University of California San Francisco California USA.
Amy WolfDepartment of Neurology, Memory and Aging Center University of California San Francisco California USA.
Isabel Elaine AllenGlobal Brain Health Institute University of California San Francisco California USA.
Stephen SallowayWarren Alpert Medical School Brown University Providence Rhode Island USA.
Jasmeer ChhatwalMassachusetts General Hospital, Harvard Medical School Boston Boston Massachusetts USA.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA.
Dolly Reyes-DumeyerTaub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA.
Randal J BatemanCharles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine St. Louis Missouri USA.
Tammie L S BenzingerCharles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine St. Louis Missouri USA.
John C MorrisCharles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine St. Louis Missouri USA.
Beau M AncesCharles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine St. Louis Missouri USA.
Nelly Joseph-MathurinCharles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine St. Louis Missouri USA.
Richard J PerrinCharles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine St. Louis Missouri USA.
Brian A GordonCharles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine St. Louis Missouri USA.
Johannes LevinGerman Center for Neurodegenerative Diseases (DZNE) Munich Germany.
Jonathan VögleinGerman Center for Neurodegenerative Diseases (DZNE) Munich Germany.
Mathias JuckerGerman Center for Neurodegenerative Diseases (DZNE) Tübingen Germany.
Christian la FougèreGerman Center for Neurodegenerative Diseases (DZNE) Tübingen Germany.
Ralph N MartinsDepartment of Biomedical Sciences Macquarie University North Ryde New South Wales Australia.
Hamid R SohrabiDepartment of Biomedical Sciences Macquarie University North Ryde New South Wales Australia.
Kevin TaddeiCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia.
Victor L VillemagneDepartment of Molecular Imaging and Therapy Austin Health Melbourne Victoria Australia.
Peter R SchofieldNeuroscience Research Australia, Randwick Sydney New South Wales Australia.
William S BrooksNeuroscience Research Australia, Randwick Sydney New South Wales Australia.
Michael FulhamDepartment of Molecular Imaging, Royal Prince Alfred Hospital, Sydney Medical School University of Sydney Camperdown New South Wales Australia.
Colin L MastersThe Florey Institute University of Melbourne Parkville Victoria Australia.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis Indiana USA.
Andrew J SaykinDepartment of Neurology Indiana University School of Medicine Indianapolis Indiana USA.
Clifford R JackDepartment of Radiology Mayo Clinic Rochester Minnesota USA.
Neill R Graff-RadfordDepartment of Neurology Mayo Clinic Jacksonville Florida USA.
Michael WeinerDepartment of Veterans Affairs Medical Center Center for Imaging of Neurodegenerative Diseases San Francisco California USA.
David M CashDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology University College London London UK.
Ricardo F AllegriDepartment of Cognitive Neurology, Neuropsychiatry and Neuropsychology Instituto de InvestigacionesNeurológicas FLENI Buenos Aires Argentina.
Patricio ChremDepartment of Cognitive Neurology, Neuropsychiatry and Neuropsychology Instituto de InvestigacionesNeurológicas FLENI Buenos Aires Argentina.
Su YiBanner Alzheimer's Institute Phoenix Arizona USA.
Bruce L MillerGlobal Brain Health Institute University of California San Francisco California USA.
Gil D RabinoviciGlobal Brain Health Institute University of California San Francisco California USA.
Howard J RosenGlobal Brain Health Institute University of California San Francisco California USA.
Dominantly Inherited Alzheimer Network
Hope Center for Neurological Disorders · USUniversity of California, San Francisco · USColumbia University · USEdith Cowan University · AUGerman Center for Neurodegenerative Diseases · DEGlobal Brain Health Institute · USUniversity Memory and Aging Center · USWashington University in St. Louis · USAustin Health · AUBanner Alzheimer’s InstituteBrown University · USFlorey Institute of Neuroscience and Mental Health · AUFundación para la Lucha contra las Enfermedades Neurológicas de la Infancia · ARHarvard University · USHertie Institute for Clinical Brain Research · DEIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineInstituto de Neurología Cognitiva · ARLudwig-Maximilians-Universität München · DEMayo Clinic · US
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MTechnology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI RICHARD Justin PERRIN · 1985 to 2026
$69.5MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI FAGAN, ANNE · 1985 to 2019
$52.1MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9MResearch Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Miguel Arce · 2020 to 2026
$30.1MNIA NIH HHS K08 AG022228NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG012435NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG072976NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG016570NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG055121NIA NIH HHS R01 AG057739NIA NIH HHS R01 AG068193NIA NIH HHS R37 AG057739NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG045390NIA NIH HHS U01 AG051218NIA NIH HHS U01 AG068057NIA NIH HHS U19 AG032438NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NIA NIH HHS UF1 AG032438NINDS NIH HHS U54 NS092089NLM NIH HHS R01 LM013463
Abstract
introductionAsymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD-MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. Brain atrophy is an early feature of DIAD-MC and could help predict risk for dementia during trial enrollment.
methodsWe created a dementia risk score by entering standardized gray-matter volumes from 231 DIAD-MC into a logistic regression to classify participants with and without dementia. The score's predictive utility was assessed using Cox models and receiver operating curves on a separate group of 65 DIAD-MC followed longitudinally.
resultsOur risk score separated asymptomatic versus demented DIAD-MC with 96.4% (standard error = 0.02) and predicted conversion to dementia at next visit (hazard ratio = 1.32, 95% confidence interval [CI: 1.15, 1.49]) and within 2 years (area under the curve = 90.3%, 95% CI [82.3%-98.2%]) and improved prediction beyond established methods based on familial age of onset. DISCUSSION: Individualized risk scores based on brain atrophy could be useful for establishing enrollment criteria and stratifying DIAD-MC participants for prevention trials.
Indexed as
autosomal dominant Alzheimer's diseasebrain atrophyDominantly Inherited Alzheimer Networkpreclinical Alzheimer's disease
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