Evidence map›Paper›PMID 34258335›Full record

ArticleNeurobiology of stress2021

αCaMKII in the lateral amygdala mediates PTSD-Like behaviors and NMDAR-Dependent LTD.

Shuming An, Jiayue Wang, Xuliang Zhang, Yanhong Duan, Yiqiong Xu, Junyan Lv, Dasheng Wang, Huan Zhang, Gal Richter-Levin, Oded Klavir and 2 more

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. GABAergic CaMKIIα+ Amygdala Output Attenuates Pain and Modulates Emotional-Motivational Behavior via Parabrachial Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Shuming AnKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Jiayue WangKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Xuliang ZhangKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Yanhong DuanKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Yiqiong XuDepartment of Anesthesiology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China.
Junyan LvKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Dasheng WangKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Huan ZhangKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
Gal Richter-Levin"Sagol" Department of Neurobiology, University of Haifa, Haifa, 31905, Israel.
Oded KlavirDepartment of Psychology, Brain and Psychopathology Division, University of Haifa, Haifa, 31905, Israel.
Buwei YuDepartment of Anesthesiology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China.
Xiaohua CaoKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
East China Normal University · CNShanghai Jiao Tong University · CNUniversity of Haifa · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that afflicts many individuals. However, its molecular and cellular mechanisms remain largely unexplored. Here, we found PTSD susceptible mice exhibited significant up-regulation of alpha-Ca

Indexed as

AmygdalaAnxietyCued fear conditioningLTDPosttraumatic stress disorder (PTSD)αCaMKII

Identifiers

PMID34258335
PMCPMC8252123
OpenAlexW3176396850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.