Evidence map›Paper›PMID 34258317›Full record

ArticleOpen forum infectious diseases2021

Humoral Immune Response to

Carolyn D Alonso, Konstantinos Papamichael, Rebecca Sprague, Caitlin Barrett, Anne J Gonzales-Luna, Kaitlyn Daugherty, Kevin W Garey, Javier Villafuerte-Gálvez, Hua Xu, Qianyun Lin and 4 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Clinical microbiology reviews · 2024
    Review
  4. Preservation of the Innate Immune Response toOpen forum infectious diseases · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Carolyn D AlonsoDivision of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3140-1128
Konstantinos PapamichaelHarvard Medical School, Boston, Massachusetts, USA.
Rebecca SpragueDivision of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2086-2583
Caitlin BarrettDivision of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7928-0890
Anne J Gonzales-LunaDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-1906-359X
Kaitlyn DaughertyDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3718-5585
Kevin W GareyDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-2063-7503
Javier Villafuerte-GálvezDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3379-5271
Hua XuDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Qianyun LinDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0001-9853-7399
Lamei WangDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Xinhua ChenDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Nira R PollockDivision of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6396-2915
Ciarán P KellyHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-8216-1240
Beth Israel Deaconess Medical Center · USUniversity of Houston · USBoston Children's Hospital · USCapital Medical University · CN

Funding

RESEARCH TRAINING IN GASTROENTEROLOGYT32DK007760 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KELLY, CIARAN P · 1999 to 2019
$4.6M
Ultrasensitive C.difficile toxin measurement for diagnosis and outcome predictionR01AI116596 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI POLLOCK, NIRA · 2016 to 2020
$4.1M
NIAID NIH HHS R01 AI116596NIDDK NIH HHS T32 DK007760
6 · The paper itself

Abstract

backgroundThe humoral immune response to

methodsWe conducted a prospective study of hospitalized adults with CDI, with and without immunosuppression (hematologic malignancy, active solid tumor, solid organ or stem cell transplant, inflammatory bowel disease, autoimmune disease, congenital or acquired immunodeficiency, asplenia, chronic receipt of high-dose steroids, or receipt of immunosuppressing medications within 12 months). Serum and stool antibody concentrations of immunoglobulin (Ig)M, IgG, and IgA to

resultsNinety-eight subjects (47 ICH; 51 non-ICH) were enrolled. Baseline serum antitoxin A and B antibody levels were similar. At day 3, ICHs demonstrated lower serum levels of antitoxin A IgG, antitoxin A IgA, and antitoxin B IgA (all

conclusionsThe ICHs with CDI demonstrated lower levels of

Indexed as

C difficile toxinsClostridioides difficile infectionhumoral immunityimmunosuppression

Identifiers

PMID34258317
PMCPMC8271131
OpenAlexW3169320382

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.