Evidence map›Paper›PMID 34258293›Full record

ReviewJournal of diabetes research2021

Potential Functions of the BMP Family in Bone, Obesity, and Glucose Metabolism.

Yao Chen, Bingwei Ma, Xingchun Wang, Xiaojuan Zha, Chunjun Sheng, Peng Yang, Shen Qu

Abstract readReview
In one paragraph

Review in Journal of diabetes research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. High-intensity interval training andResearch in pharmaceutical sciences · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Potential Role of BMP7 in Regenerative Dentistry.International dental journal · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. The Influence of BMP6 on Serotonin and Glucose Metabolism.International journal of molecular sciences · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yao ChenChengdu Second People's Hospital, Chengdu 610017, China.
Bingwei MaDepartment of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Xingchun WangThyroid Research Center of Shanghai, Shanghai 200072, China.ORCID https://orcid.org/0000-0003-3777-2525
Xiaojuan ZhaThyroid Research Center of Shanghai, Shanghai 200072, China.
Chunjun ShengThyroid Research Center of Shanghai, Shanghai 200072, China.
Peng YangThyroid Research Center of Shanghai, Shanghai 200072, China.
Shen QuThyroid Research Center of Shanghai, Shanghai 200072, China.ORCID https://orcid.org/0000-0003-0811-7070

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Characteristic bone metabolism was observed in obesity and diabetes with controversial conclusions. Type 2 diabetes (T2DM) and obesity may manifest increased bone mineral density. Also, obesity is more easily to occur in T2DM. Therefore, we infer that some factors may be linked to bone and obesity as well as glucose metabolism, which regulate all of them. Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor- (TGF-) beta superfamily, regulate a diverse array of cellular functions during development and in the adult. More and more studies revealed that there exists a relationship between bone metabolism and obesity as well as glucose metabolism. BMP2, BMP4, BMP6, BMP7, and BMP9 have been shown to affect the pathophysiological process of obesity and glucose metabolism beyond bone metabolism. They may exert functions in adipogenesis and differentiation as well as insulin resistance. In the review, we summarize the literature on these BMPs and their association with metabolic diseases including obesity and diabetes.

Indexed as

AdipogenesisAdipose TissueBone and BonesBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Bone Morphogenetic Protein 6Bone Morphogenetic Protein 7Bone Morphogenetic ProteinsCell DifferentiationDiabetes Mellitus, Type 2GlucoseGrowth Differentiation Factor 2HumansInsulin ResistanceObesityBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Bone Morphogenetic Protein 6Bone Morphogenetic Protein 7Bone Morphogenetic ProteinsGlucoseGrowth Differentiation Factor 2

Identifiers

PMID34258293
PMCPMC8249130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.