Evidence map›Paper›PMID 34258288›Full record

ArticleBioMed research international2021

Impact of Adenosine Analogue, Adenosine-5'-N-Ethyluronamide (NECA), on Insulin Signaling in Skeletal Muscle Cells.

Mansour Haddad

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mansour HaddadFaculty of Pharmacy, Philadelphia University, Amman, Jordan.ORCID https://orcid.org/0000-0002-3463-7152
Philadelphia University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MATERIALS AND

methodsRat L6 skeletal muscle cells were cultured in 25 cm

resultsAdenosine-5'-N-ethyluronamide (NECA), a stable adenosine analogue, significantly stimulate inflammatory mediator (IL-6) (

conclusionsA novel crosstalk between adenosine analogue and insulin has been demonstrated for the first time; evidence has been gathered in vitro for the effects of NECA and insulin treatment on intracellular signaling pathways, in particular glycolysis and insulin sensitivity in skeletal muscle cells.

Indexed as

Acetyl-CoA CarboxylaseAcyl-CoA Dehydrogenase, Long-ChainAdenosineAdenosine-5'-(N-ethylcarboxamide)AnimalsCarnitine O-PalmitoyltransferaseHexokinaseInflammationInsulinInterleukin-6Muscle Fibers, SkeletalMuscle, SkeletalMyoblastsNuclear Receptor Subfamily 4, Group A, Member 1Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphofructokinasesAcetyl-CoA CarboxylaseAcyl-CoA Dehydrogenase, Long-ChainAdenosineAdenosine-5'-(N-ethylcarboxamide)Carnitine O-PalmitoyltransferaseCPT1b protein, ratHexokinaseInsulinInterleukin-6Nr4a1 protein, ratNuclear Receptor Subfamily 4, Group A, Member 1Pdk4 protein, ratPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphofructokinasesPpargc1a protein, ratPyruvate Dehydrogenase Acetyl-Transferring KinaseReceptors, Cytoplasmic and NuclearTranscription Factors

Identifiers

PMID34258288
PMCPMC8257337
OpenAlexW3175798793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.