Evidence map›Paper›PMID 34258168›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Diclofenac Resensitizes Methicillin-Resistant

Shutao Zhang, Xinhua Qu, Haozheng Tang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07237620 (Comparison of Calcium Hydroxide and Diclofenac Sodium as Intracanal Medicaments on Periapical Healing), which is not on this map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07237620 narecruitingnot on this mapstarted 2025, after this paper: background citation

Comparison of Calcium Hydroxide and Diclofenac Sodium as Intracanal Medicaments on Periapical Healing: A Fractal Analysis Study

TypeinterventionalSponsorMustafa Kemal UniversityRan2025 to 2027Enrolled60ConditionsPeriapical Lesion Healing, Apical PeriodontitisArmsDiclofenac sodium
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 67 citations in OpenAlex.

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  15. Mechanistic Evaluation of LolA andInternational journal of microbiology · 2026
    Article
  16. Article
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  18. Drug Repurposing: An Emerging Strategy inJournal of microbiology and biotechnology · 2025
    Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shutao ZhangDepartment of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine Shanghai Jiaotong University Shanghai 200127 China.
Xinhua QuDepartment of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine Shanghai Jiaotong University Shanghai 200127 China.
Haozheng TangDepartment of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine Shanghai Jiaotong University Shanghai 200127 China.
You WangDepartment of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine Shanghai Jiaotong University Shanghai 200127 China.
Hongtao YangDepartment of Plastic & Reconstructive Surgery The Ohio State University Columbus OH 43210 USA.
Weien YuanEngineering Research Center of Cell & Therapeutic Antibody Ministry of Education School of Pharmacy Shanghai Jiao Tong University Shanghai 200240 China.
Bing YueDepartment of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine Shanghai Jiaotong University Shanghai 200127 China.ORCID 0000-0002-3279-9676
Renji Hospital · CNShanghai Jiao Tong University · CNThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant infections caused by methicillin-resistant

Indexed as

AnimalsAnti-Bacterial AgentsAnti-Inflammatory Agents, Non-Steroidalbeta-LactamsDiclofenacDisease Models, AnimalFemaleMethicillin-Resistant Staphylococcus aureusMiceProstheses and ImplantsAnti-Bacterial AgentsAnti-Inflammatory Agents, Non-Steroidalbeta-LactamsDiclofenacdiclofenacmethicillin‐resistant Staphylococcus aureusoxacillinperioperative infection

Identifiers

PMID34258168
PMCPMC8261494
OpenAlexW3157365769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.