ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
Manipulation and Mixing of 200 Femtoliter Droplets in Nanofluidic Channels Using MHz-Order Surface Acoustic Waves.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Surface Acoustic Wave Devices: New Mechanisms, Enabling Techniques, and Application Frontiers.Micromachines · 2026Review
- Fluid Flow Measurements in Nanoslits Using Holographic Microscopy.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Acoustofluidic Tweezers Integrated with Droplet Sensing Enable Multifunctional Closed-Loop Droplet Manipulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Wireless Frequency-Multiplexed Acoustic Array-based Acoustofluidics.Advanced materials technologies · 2024Article
- A Miniaturized Wireless Micropump Enabled by Confined Acoustic Streaming.Research (Washington, D.C.) · 2024Article
- Aerosol jet printing of surface acoustic wave microfluidic devices.Microsystems & nanoengineering · 2024Article
- In vivo acoustic manipulation of microparticles in zebrafish embryos.Science advances · 2022Article
- Manipulation and Mixing of 200 Femtoliter Droplets in Nanofluidic Channels Using MHz-Order Surface Acoustic Waves.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controllable manipulation and effective mixing of fluids and colloids at the nanoscale is made exceptionally difficult by the dominance of surface and viscous forces. The use of megahertz (MHz)-order vibration has dramatically expanded in microfluidics, enabling fluid manipulation, atomization, and microscale particle and cell separation. Even more powerful results are found at the nanoscale, with the key discovery of new regimes of acoustic wave interaction with 200 fL droplets of deionized water. It is shown that 40 MHz-order surface acoustic waves can manipulate such droplets within fully transparent, high-aspect ratio, 100 nm tall, 20-130 micron wide, 5-mm long nanoslit channels. By forming traps as locally widened regions along such a channel, individual fluid droplets may be propelled from one trap to the next, split between them, mixed, and merged. A simple theory is provided to describe the mechanisms of droplet transport and splitting.
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Registered trials
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