ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
Long-Term Imaging of Wound Angiogenesis with Large Scale Optoacoustic Microscopy.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- S1 guideline for imaging diagnostics for skin diseases.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Guideline
- A handheld photoacoustic microscopic probe integrating a transparent ultrasound transducer and a fiber scanner.Nature communications · 2025Article
- Pilose antler extract promotes angiogenesis and vascular maturation to accelerate wound healing.Scientific reports · 2025Article
- Water, Collagen, and Lipid Content in the Human Skin and Muscles Assessed with Near-Infrared Diffuse Reflectance Spectroscopy and Multi-Spectral Optoacoustic Tomography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Catalyst-modulated hydrogel dynamics for decoupling viscoelasticity and directing macrophage fate for diabetic wound healing.Bioactive materials · 2025Article
- Local laser fluence estimation in optical resolution optoacoustic angiography employing calibrated ultrasound detector.Photoacoustics · 2025Article
- Article
- The Potential of Photoacoustic Imaging in Detecting and Managing Complex Wounds.Biomaterials research · 2025Review
- Recombinant human collagen type III microgel: an advanced injectable dermal filler for rejuvenating aging skin.Regenerative biomaterials · 2025Article
- Skin layer-specific spatiotemporal assessment of micrometabolism during wound angiogenesis.Communications biology · 2024Article
- Nanoporous Submicron Gold Particles Enable Nanoparticle-Based Localization Optoacoustic Tomography (nanoLOT).Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Evaluations of a Cutaneous Wound Healing Model Using Oxygen Enhanced - Dynamic Contrast Enhanced Photoacoustic Imaging (OE-DCE PAI).Molecular imaging and biology · 2024Article
- Enhanced dual-mode imaging: Superior photoacoustic and ultrasound endoscopy in live pigs using a transparent ultrasound transducer.Science advances · 2024Article
- TowardsFundamental research · 2024Review
- Scanning optoacoustic angiography for assessing structural and functional alterations in superficial vasculature of patients with post-thrombotic syndrome: A pilot study.Photoacoustics · 2024Article
- Wound management materials and technologies from bench to bedside and beyond.Nature reviews. Materials · 2024Article
- The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration.Biomedicines · 2024Review
- Applications of mesenchymal stem cell-exosome components in wound infection healing: new insights.Burns & trauma · 2024Review
- Large-field-of-view optical-resolution optoacoustic microscopy using a stationary silicon-photonics acoustic detector.Journal of biomedical optics · 2024Article
- 3D imaging of aqueous veins and surrounding sclera using a dual-wavelength photoacoustic microscopy.Biomedical optics express · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing is a well-coordinated process, necessitating efficient formation of new blood vessels. Vascularization defects are therefore a major risk factor for chronic, non-healing wounds. The dynamics of mammalian tissue revascularization, vessel maturation, and remodeling remain poorly understood due to lack of suitable in vivo imaging tools. A label-free large-scale optoacoustic microscopy (LSOM) approach is developed for rapid, non-invasive, volumetric imaging of tissue regeneration over large areas spanning up to 50 mm with a depth penetration of 1.5 mm. Vascular networks in dorsal mouse skin and full-thickness excisional wounds are imaged with capillary resolution during the course of healing, revealing previously undocumented views of the angiogenesis process in an unperturbed wound environment. Development of an automatic analysis framework enables the identification of key features of wound angiogenesis, including vessel length, diameter, tortuosity, and angular alignment. The approach offers a versatile tool for preclinical research in tissue engineering and regenerative medicine, empowering label-free, longitudinal, high-throughput, and quantitative studies of the microcirculation in processes associated with normal and impaired vascular remodeling, and analysis of vascular responses to pharmacological interventions in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.