ArticleJournal of nutrition and metabolism2021
The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity.
Article in Journal of nutrition and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Hepcidin and inflammation associated with iron deficiency in childhood obesity - A systematic review.Jornal de pediatriaPooled it
- Associations of Serum Zinc and Iron with Systemic Inflammatory Indices in Pediatric Obesity: An Exploratory Cross-Sectional Study.Children (Basel, Switzerland) · 2026Article
- The Interplay Between Iron Metabolism and Insulin Resistance: A Key Factor in Optimizing Obesity Management in Children and Adolescents.Nutrients · 2025Review
- The Impact of Paediatric Obesity on Drug Pharmacokinetics: A Virtual Clinical Trials Case Study with Amlodipine.Pharmaceutics · 2024Article
- Review
- Comparison between School-Age Children with and without Obesity in Nutritional and Inflammation Biomarkers.Journal of clinical medicine · 2022Article
- Association between Obesity and Anemia in a Nationally Representative Sample of South Korean Adolescents: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIron deficiency (ID) is the most common nutritional deficiency found in pediatric practice. A higher prevalence of ID may be found in children with obesity. Obesity is a chronic low-grade inflammatory condition. It is postulated that inflammation increases hepcidin, a regulator of iron homeostasis. The aim of this study was to investigate the associations between iron status, hepcidin, and BMI-standard deviation score (BMI-SDS) in children with and without obesity.
methodsA cross-sectional study of Thai children with obesity (5 to 15 years old) versus age- and sex-matched, nonobese controls was conducted. A total of 63 children with obesity and 27 controls were enrolled. Complete blood count, serum iron, ferritin, transferrin saturation, and total iron binding capacity were analyzed. Serum hepcidin-25 was assayed using a hepcidin ELISA Kit (Human Hepc25).
resultsThere were 63 children with obesity, the median age (IQR) being 10 (9-13) years, and 27 controls. The median (IQR) BMI-SDS of the obese group was 2.3 (2.0-2.6) vs. -0.5 ((-1.3)-0.4) of the control group. ID was diagnosed in 27 children in the obese group (42.9%); 4 of the children with obesity and ID had anemia. Serum hepcidin-25 levels of the children with ID vs. without ID in the obese group were not significantly different (median (IQR) 25 (12.9-49.2) and 26.4 (12.6-43.6), respectively) but both of them were significantly higher than controls (19.7 (8.3-25.5) ng/ml,
conclusionPrevalence of iron deficiency in Thai children with obesity and serum hepcidin-25 was higher than controls. Further study in a larger population, preferably with interventions such as weight loss program, is warranted to clarify this association.
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Registered trials
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