Evidence map›Paper›PMID 34257791›Full record

ArticleRadiology case reports2021

Cerebral amyloid angiopathy related inflammation: A little known but not to be underestimated disease.

Daniela Grasso, Giulia Castorani, Carmela Borreggine, Annalisa Simeone, Roberto De Blasi

Open access · goldAbstract readCase Reports
In one paragraph

Article in Radiology case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. A perspective: PLA2G4A as drug target for vascular inflammation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Cerebral amyloid angiopathy: a narrative review.Frontiers in aging neuroscience · 2025
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Daniela GrassoIRCCS Ospedale Casa Sollievo della Sofferenza, Department of Diagnostic Imaging, San Giovanni Rotondo, Italy.
Giulia CastoraniUniversity of Foggia Postgraduate Medical School, Diagnostic Imaging, Foggia, Italy.
Carmela BorreggineIRCCS Ospedale Casa Sollievo della Sofferenza, Department of Diagnostic Imaging, San Giovanni Rotondo, Italy.
Annalisa SimeoneIRCCS Ospedale Casa Sollievo della Sofferenza, Department of Diagnostic Imaging, San Giovanni Rotondo, Italy.
Roberto De BlasiDepartment of Diagnostic Imaging, Tricase, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITCasa Sollievo della Sofferenza · ITUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral amyloid angiopathy related inflammation (CAA-ri) is a rare encephalopathy resulting from perivascular inflammation after β-βamyloid (A) deposition in cerebral vessels leading to progressive dementia, focal neurological signs, seizures and intracerebral hemorrhages. This condition is characterized on magnetic resonance imaging (MRI) by patchy or confluent T2/fluid attenuation inversion recovery (FLAIR) hyperintensities in the cortex and subcortical white matter located mainly in the same areas of pre-existing multiple microhemorrhages. In this report of 2 cases of "probable" CAA-ri women aged 71 and 68, we propose a review on the pathophysiological, clinical, radiological, therapeutic and prognostic aspects of this little-known and poor outcome condition. Even though an apparently favorable initial evolution after steroid and/or immunosuppressive treatment, CAA-ri course is unpredictable and often associated with low survival rates. We suggest the importance of timely and proper clinico-radiological evaluation in suspected CAA-ri cases, in order to start an appropriate treatment even without the brain biopsy.

Indexed as

Cerebral amyloid angiopathyInflammationMicrobleedsMRSusceptibility weighted imaging

Identifiers

PMID34257791
PMCPMC8260958
OpenAlexW3178577879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.