Evidence map›Paper›PMID 34257687›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

Production of an Animal Model of Semi-Yin and Semi-Yang Syndrome with Diabetic Ulcers and Study of Its Pathological and Metabolic Features.

Yu Liu, Jian-Ping Shi, Wu Xiong, Yang Liu, Yu Yan, Chao-Qi Yin, Yu-Qi Jiao, Xi Zhang, Jian-Da Zhou

Open access · hybridAbstract read
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In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yu LiuPostdoctoral Research Station of Clinical Medicine & Department of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Jian-Ping ShiInner Mongolia Medical University, Hohhot 010000, China.
Wu XiongThe First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China.
Yang LiuDepartment of Plast Surg, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Yu YanDepartment of Plast Surg, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Chao-Qi YinDepartment of Plast Surg, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Yu-Qi JiaoInner Mongolia Medical University, Hohhot 010000, China.
Xi ZhangClinical Medical College of Hunan University of Chinese Medicine, Changsha 410007, China.ORCID https://orcid.org/0000-0001-8617-7111
Jian-Da ZhouDepartment of Plast Surg, The Third Xiangya Hospital, Central South University, Changsha 410013, China.ORCID https://orcid.org/0000-0003-2760-2389
Central South University · CNInner Mongolia Medical University · CNFirst Affiliated Hospital of Hunan University of Traditional Chinese Medicine · CNHunan University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo create an animal model for diabetic ulcers with semi-Yin and semi-Yang (SYSY) syndrome and to study the pathological and metabolic features of SYSY syndrome.

methodsFirstly, based on the clinical characteristics of the SYSY syndrome of diabetic ulcer, an animal model of diabetic ulcers with SYSY syndrome being full-thickness skin defects was created by injecting streptozotocin (STZ) intraperitoneally, infecting with

resultsAn animal model of diabetic ulcers with SYSY syndrome was established. The pathological features of the SYSY syndrome group were chronic low-grade inflammatory reactions. On the third day, the SYSY syndrome group displayed lower expression of CD16, CD68, CD163, IL-1

conclusionSYSY syndrome presents a persistent pathological state of low inflammation, which may be caused by an insufficient activation of the M1-type metabolic pathway in macrophages in the early acute inflammatory stage, resulting in the incomplete clearance of pathogens and debris and continuous stimulation of macrophages to initiate the M1-type metabolic pathway. CD163, CD31, IL-10, and citric acid can be used as potential specific markers for the recovery and progression of SYSY syndrome.

Identifiers

PMID34257687
PMCPMC8257356
OpenAlexW3176784899

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.