Evidence map›Paper›PMID 34257409›Full record

ReviewMolecular psychiatry2022

Treatment resistance in psychiatry: state of the art and new directions.

Oliver D Howes, Michael E Thase, Toby Pillinger

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 196 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Oliver D HowesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. oliver.howes@kcl.ac.uk.
Michael E ThaseDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, USA.
Toby PillingerInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6074-2626

Funding

Department of HealthMedical Research Council MC_A656_5QD30_2135Medical Research Council MC_U120097115Medical Research Council MR/N027078/1Wellcome TrustWellcome Trust 094849/Z/10/Z
6 · The paper itself

Abstract

Treatment resistance affects 20-60% of patients with psychiatric disorders; and is associated with increased healthcare burden and costs up to ten-fold higher relative to patients in general. Whilst there has been a recent increase in the proportion of psychiatric research focussing on treatment resistance (R

Indexed as

Bipolar DisorderMajor Depressive DisorderObsessive-Compulsive DisorderPanic DisorderPsychiatryHumans

Identifiers

PMID34257409
PMCPMC8960394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.