Evidence map›Paper›PMID 34257382›Full record

ArticleScientific reports2021

A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men.

Blanca Marin Bosch, Aurélien Bringard, Maria G Logrieco, Estelle Lauer, Nathalie Imobersteg, Aurélien Thomas, Guido Ferretti, Sophie Schwartz, Kinga Igloi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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  19. Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Blanca Marin BoschDepartment of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Aurélien BringardDepartment of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Maria G LogriecoDepartment of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Estelle LauerUnit of Toxicology, CURML, Lausanne University Hospital and Geneva University Hospitals, Geneva, Switzerland.
Nathalie ImoberstegDepartment of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Aurélien ThomasUnit of Toxicology, CURML, Lausanne University Hospital and Geneva University Hospitals, Geneva, Switzerland.
Guido FerrettiDepartment of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Sophie Schwartz *Department of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Kinga Igloi *Department of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland. kinga.igloi@unige.ch.
University of Geneva · CHUniversity Hospital of Geneva · CHUniversity Centre of Legal Medicine · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular physical exercise enhances memory functions, synaptic plasticity in the hippocampus, and brain derived neurotrophic factor (BDNF) levels. Likewise, short periods of exercise, or acute exercise, benefit hippocampal plasticity in rodents, via increased endocannabinoids (especially anandamide, AEA) and BDNF release. Yet, it remains unknown whether acute exercise has similar effects on BDNF and AEA levels in humans, with parallel influences on memory performance. Here we combined blood biomarkers, behavioral, and fMRI measurements to assess the impact of a single session of physical exercise on associative memory and underlying neurophysiological mechanisms in healthy male volunteers. For each participant, memory was tested after three conditions: rest, moderate or high intensity exercise. A long-term memory retest took place 3 months later. At both test and retest, memory performance after moderate intensity exercise was increased compared to rest. Memory after moderate intensity exercise correlated with exercise-induced increases in both AEA and BNDF levels: while AEA was associated with hippocampal activity during memory recall, BDNF enhanced hippocampal memory representations and long-term performance. These findings demonstrate that acute moderate intensity exercise benefits consolidation of hippocampal memory representations, and that endocannabinoids and BNDF signaling may contribute to the synergic modulation of underlying neural plasticity mechanisms.

Indexed as

ExerciseMemoryAdolescentAdultArachidonic AcidsBehaviorBiomarkersBrain-Derived Neurotrophic FactorEndocannabinoidsExercise TherapyHeart RateHippocampusHumansLearningMagnetic Resonance ImagingMaleanandamideArachidonic AcidsBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorEndocannabinoidsPolyunsaturated Alkamides

Identifiers

PMID34257382
PMCPMC8277796
OpenAlexW3180043482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.