ArticleScientific reports2021
The effect of decongestion on nasal airway patency and airflow.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Olfactory Sequelae of Nasal Surgeries: A Systematic Review with Meta-Analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialePooled it
- Ectoine as a multifunctional molecule: biotechnological production and pharmaceutical applications.Drug delivery and translational research · 2026Review
- Creating nasal cycle simulations by processing MRI and CT scan data with image morphing algorithms.Scientific reports · 2025Article
- Part 1 - imidazolines and the changing face of nasal decongestants.Frontiers in pharmacology · 2025Review
- The effect of including dynamic imaging derived airway wall motion in CFD simulations of respiratory airflow in patients with OSA.Scientific reports · 2024Article
- Effects of Mucosal Decongestion on Nasal Aerodynamics: A Pilot Study.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Article
- Effects of decongestion on nasal cavity air conditioning efficiency: a CFD cohort study.Scientific reports · 2024Article
- Assessing Nasal Epithelial Dynamics: Impact of the Natural Nasal Cycle on Intranasal Spray Deposition.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Numerical and Experimental Analysis of Drug Inhalation in Realistic Human Upper Airway Model.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Asymmetrical nasal high flow ventilation improves clearance of COJournal of applied physiology (Bethesda, Md. : 1985) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nasal decongestant reduces blood flow to the nasal turbinates, reducing tissue volume and increasing nasal airway patency. This study maps the changes in nasal anatomy and measures how these changes affect nasal resistance, flow partitioning between superior and inferior cavity, flow patterns and wall shear stress. High-resolution MRI was applied to capture nasal anatomy in 10 healthy subjects before and after application of a topical decongestant. Computational fluid dynamics simulated nasal airflow at steady inspiratory flow rates of 15 L.min[Formula: see text] and 30 L.min[Formula: see text]. The results show decongestion mainly increases the cross-sectional area in the turbinate region and SAVR is reduced (median approximately 40[Formula: see text] reduction) in middle and lower parts of the cavity. Decongestion reduces nasal resistance by 50[Formula: see text] on average, while in the posterior cavity, nasal resistance decreases by a median factor of approximately 3 after decongestion. We also find decongestant regularises nasal airflow and alters the partitioning of flow, significantly decreasing flow through the superior portions of the nasal cavity. By comparing nasal anatomies and airflow in their normal state with that when pharmacologically decongested, this study provides data for a broad range of anatomy and airflow conditions, which may help characterize the extent of nasal variability.
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