ArticleNature communications2021
Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Microrchidia ATPases and DNA 6mA demethylase ALKBH1 act antagonistically on PRC2 to control chromatin structure and stress tolerance.Nature plants · 2025Article
- High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes.Nature microbiology · 2025Article
- REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes.Nature cell biology · 2025Article
- Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism inScience advances · 2025Article
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- Microrchidia OsMORC6 Positively Regulates Cadmium Tolerance and Uptake by Mediating DNA Methylation in Rice.Rice (New York, N.Y.) · 2025Article
- Domestication history and genetic changes for the newly evolved flower color in the ornamental plantHorticulture research · 2025Article
- Article
- Heterochromatin in plant meiosis.Nucleus (Austin, Tex.) · 2024Review
- The MBD-ACD DNA methylation reader complex recruits MICRORCHIDIA6 to regulate ribosomal RNA gene expression in Arabidopsis.The Plant cell · 2024Article
- Mind the gap: Epigenetic regulation of chromatin accessibility in plants.Plant physiology · 2024Review
- How intrinsically disordered proteins order plant gene silencing.Trends in genetics : TIG · 2024Review
- Mapping nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL.Nature communications · 2024Article
- circMORC3-encoded novel protein negatively regulates antiviral immunity through synergizing with host gene MORC3.PLoS pathogens · 2023Article
- DDT-RELATED PROTEIN4-IMITATION SWITCH alters nucleosome distribution to relieve transcriptional silencing in Arabidopsis.The Plant cell · 2023Article
- The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.Nature communications · 2023Article
- MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions.Genome biology · 2023Article
- Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing.Life science alliance · 2023Article
- A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis.Nature plants · 2023Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
The Microrchidia (MORC) family of ATPases are required for transposable element (TE) silencing and heterochromatin condensation in plants and animals, and C. elegans MORC-1 has been shown to topologically entrap and condense DNA. In Arabidopsis thaliana, mutation of MORCs has been shown to reactivate silent methylated genes and transposons and to decondense heterochromatic chromocenters, despite only minor changes in the maintenance of DNA methylation. Here we provide the first evidence localizing Arabidopsis MORC proteins to specific regions of chromatin and find that MORC4 and MORC7 are closely co-localized with sites of RNA-directed DNA methylation (RdDM). We further show that MORC7, when tethered to DNA by an artificial zinc finger, can facilitate the establishment of RdDM. Finally, we show that MORCs are required for the efficient RdDM mediated establishment of DNA methylation and silencing of a newly integrated FWA transgene, even though morc mutations have no effect on the maintenance of preexisting methylation at the endogenous FWA gene. We propose that MORCs function as a molecular tether in RdDM complexes to reinforce RdDM activity for methylation establishment. These findings have implications for MORC protein function in a variety of other eukaryotic organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.