ArticleNature communications2021
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Heat stress enhances gut microbial arginine catabolism to amplify MyD88-dependent inflammatory responses.Microbiome · 2026Article
- Evaluation of clinically relevant sevoflurane concentrations in the development of malignant hyperthermia in an Ryr1 mutant mouse model.BMC anesthesiology · 2026Article
- Intracellular calcium handling dysfunction contributes to behavioural deficits leading to mortality of honey bees after acute contact exposure to the insecticide cyantraniliprole.Scientific reports · 2026Article
- Clinical and Genetic Spectrum ofMolecular syndromology · 2026Article
- Cryo-EM Brings the Mechanisms of Activation, Inactivation, and Inhibition of Ryanodine Receptors into Focus.Advances in experimental medicine and biology · 2026Review
- A New Paradigm for Precision Medicine in Heatstroke: From Molecular Subtyping to Targeted Prevention and Treatment.Journal of inflammation research · 2026Review
- Review
- Phosphorylation of RYR1 at SerScience signaling · 2025Article
- RyR1-mediated CaProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.Structure (London, England : 1993) · 2025Article
- Heatstroke-Induced Inflammatory Response and Therapeutic Biomarkers.Biomedicines · 2025Review
- Advances in the comprehensive mechanisms, diagnosis, and treatment of heatstroke-induced coagulopathy.Frontiers in cell and developmental biology · 2025Review
- Expanding diverse horizons in smooth muscle research: a symposium review of "Muscle and Pathology/Health: Frontiers of Translational Research" at the 66th Annual Meeting of Japan Society of Smooth Muscle Research.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025Review
- Advances in malignant hyperthermia: novel insights into heat-induced CaJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025Review
- Myopathic manifestations across the adult lifespan of patients with malignant hyperthermia susceptibility: a narrative review.British journal of anaesthesia · 2024Review
- Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy.Open medicine (Warsaw, Poland) · 2024Article
- Trans-scale thermal signaling in biological systems.Journal of biochemistry · 2023Review
- Three-dimensional perspective on ryanodine receptor mutations causing skeletal and cardiac muscle-related diseases.Current opinion in pharmacology · 2023Review
- Adipose Tissue Remodeling in Pathophysiology.Annual review of pathology · 2023Review
- Development of Ryanodine Receptor (RyR) Inhibitors for Skeletal Muscle and Heart Diseases.Juntendo Iji zasshi = Juntendo medical journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 8 institutions in 3 countries.
Toshiko Yamazawa *Department of Molecular Physiology, The Jikei University School of Medicine, Tokyo, Japan. toshiko1998@jikei.ac.jp.ORCID 0000-0002-4368-4794
Takuya Kobayashi *Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.ORCID 0000-0003-3992-1889
Nagomi Kurebayashi *Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.ORCID 0000-0002-5005-9698
Masato KonishiDepartment of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.
Satoru NoguchiDepartment of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID 0000-0001-6165-3716
Takayoshi InoueDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID 0000-0001-7155-2150
Yukiko U InoueDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID 0000-0002-4105-9127
Ichizo NishinoDepartment of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID 0000-0001-9452-112X
Shuichi MoriInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroto IinumaInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Noriaki ManakaInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroyuki KagechikaInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Arkady UryashDepartment of Neonatology, Mount Sinai Medical Center, Miami, FL, USA.ORCID 0000-0003-1434-8342
Jose AdamsDepartment of Neonatology, Mount Sinai Medical Center, Miami, FL, USA.
Jose R LopezDepartment of Research, Mount Sinai Medical Center, Miami, FL, USA.
Xiaochen LiuLeeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, St James's University Hospital, Leeds, UK.
Christine DiggleLeeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, St James's University Hospital, Leeds, UK.
Paul D AllenLeeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, St James's University Hospital, Leeds, UK.
Sho KakizawaDepartment of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Keigo IkedaCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.
Bangzhong LinCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.ORCID 0000-0001-5877-949X
Yui IkemiCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.ORCID 0000-0001-5687-8988
Kazuto NunomuraCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.ORCID 0000-0002-6444-3244
Shinsaku NakagawaCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.
Takashi SakuraiDepartment of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.ORCID 0000-0001-9515-6574
Takashi MurayamaDepartment of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan. takashim@juntendo.ac.jp.ORCID 0000-0002-3845-2980
Juntendo University · JPThe University of Osaka · JPNational Center of Neurology and Psychiatry · JPTokyo Medical and Dental University · JPMount Sinai Medical Center · USUniversity of Leeds · GBJikei University School of Medicine · JPKyoto University · JP
Funding
Mechanisms controlling Ca2+ dyshomeostasis in MH susceptible miceR01AR068897 · NIAMS · UNIVERSITY OF LEEDS · PI ALLEN, PAUL D · 2016 to 2020
$1.2MNIAMS NIH HHS R01 AR068897
Abstract
Mutations in the type 1 ryanodine receptor (RyR1), a Ca
Indexed as
AnimalsCalciumCalcium Channel BlockersHalothaneIsofluraneMalignant HyperthermiaMiceMuscle, SkeletalMutationRyanodine Receptor Calcium Release ChannelCalciumCalcium Channel BlockersHalothaneIsofluraneRyanodine Receptor Calcium Release Channel
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.