Evidence map›Paper›PMID 34256967›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2022

Development of a Symptom-Focused Model to Guide the Prescribing of Antipsychotics in Children and Adolescents: Results of the First Phase of the Safer Use of Antipsychotics in Youth (SUAY) Clinical Trial.

Robert B Penfold, Ella E Thompson, Robert J Hilt, Nadine Schwartz, Adelaide S Robb, Christoph U Correll, Douglas Newton, Kelly Rogalski, Marian F Earls, Robert A Kowatch and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03448575 (A Targeted Approach To A Safer Use of Antipsychotics In Youth), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03448575 nacompletednot on this map

A Targeted Approach To A Safer Use of Antipsychotics In Youth

TypeinterventionalSponsorKaiser PermanenteRan2018 to 2021Enrolled733ConditionsChild Behavior DisordersArmsControl - Provider Medication Alert Only, Intervention - Alert + CAP Review AND Enhanced BH Access
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Safer and targeted use of antipsychotics in youth: an embedded, pragmatic randomized trial.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Robert B PenfoldDrs. Penfold, Simon, and Ms. Thompson are with Kaiser Permanente Washington Health Research Institute, Seattle. Electronic address: robert.b.penfold@kp.org.
Ella E ThompsonDrs. Penfold, Simon, and Ms. Thompson are with Kaiser Permanente Washington Health Research Institute, Seattle.
Robert J HiltDr. Hilt is with Seattle Children's Hospital, Washington.
Nadine SchwartzDrs. Schwartz, Kowatch, and Kelleher are with Nationwide Children's Hospital, Columbus, Ohio.
Adelaide S RobbDr. Robb is with Children's National Hospital, Washington, DC.
Christoph U CorrellDr. Correll is with The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York; Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York; The Feinstein Institute for Medical Research, Manhasset, New York; and Charité Universitätsmedizin Berlin, Germany.
Douglas NewtonDr. Newton is with Sondermind, Denver, Colorado. At the time of the study, Dr. Newton was with Optum Behavioral Health, Denver, Colorado.
Kelly RogalskiDr. Rogalski is with Henry Ford Health System, Detroit, Michigan.
Marian F EarlsDr. Earls is with Community Care of North Carolina, Raleigh.
Robert A KowatchDrs. Schwartz, Kowatch, and Kelleher are with Nationwide Children's Hospital, Columbus, Ohio.
Arne BeckDr. Beck is with Kaiser Permanente Colorado Institute for Health Research, Denver.
Bobbi Jo H YarboroughDr. Yarborough is with Kaiser Permanente Northwest Center for Health Research, Portland, Oregon.
Stephen CrystalDr. Crystal is with Rutgers University, Brunswick, New Jersey.
Benedetto VitielloDr. Vitiello is with Università degli Studi di Torino, Turin, Italy.
Kelly J KelleherDrs. Schwartz, Kowatch, and Kelleher are with Nationwide Children's Hospital, Columbus, Ohio.
Gregory E SimonDrs. Penfold, Simon, and Ms. Thompson are with Kaiser Permanente Washington Health Research Institute, Seattle.

Funding

New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
SMINET: Applying Evidence to Improve Care and Outcomes in Severe Mental IllnessR18HS023258 · AHRQ · RUTGERS, THE STATE UNIV OF N.J. · PI CRYSTAL, STEPHEN · 2014 to 2017
$3.7M
Advancing Patient Safety for Antipsychotic-Treated Children: Examining State Implementation of Safe Use PracticesR01HS026001 · AHRQ · RUTGERS, THE STATE UNIV OF N.J. · PI CRYSTAL, STEPHEN · 2018 to 2022
$1.9M
AHRQ HHS R01 HS026001AHRQ HHS R18 HS023258NCATS NIH HHS UL1 TR003017NIDA NIH HHS HHSN271201600002C
6 · The paper itself

Abstract

objectiveTo develop a new approach to prescribing guidelines as part of a pragmatic trial, Safer Use of Antipsychotics in Youth (SUAY; ClinicalTrials.gov Identifier: NCT03448575), which supports prescribers in delivering high-quality mental health care to youths.

methodA nominal group technique was used to identify first- to nth-line treatments for target symptoms and potential diagnoses. The panel included US pediatricians, child and adolescent psychiatrists, and psychopharmacology experts. Meeting materials included information about Medicaid review programs, systematic reviews, prescribing guidelines, and a description of the pragmatic trial. Afterward, a series of 4 webinar discussions were held to achieve consensus on recommendations.

resultsThe panel unanimously agreed that the guideline should focus on target symptoms rather than diagnoses. Guidance included recommendations for first- to nth-line treatment of target mental health symptoms, environmental factors to be addressed, possible underlying diagnoses that should first be considered and ruled out, and general considerations for pharmacological and therapeutic treatments.

conclusionPrescribing guidelines are often ignored because they do not incorporate the real-world availability of first-line psychosocial treatments, comorbid conditions, and clinical complexity. Our approach addresses some of these concerns. If the approach proves successful in our ongoing pragmatic trial, Safer Use of Antipsychotics in Youth (SUAY), it may serve as a model to state Medicaid programs and health systems to support clinicians in delivering high-quality mental health care to youths. CLINICAL TRIAL REGISTRATION INFORMATION: Safer Use of Antipsychotics in Youth; http://clinicaltrials.gov/; NCT03448575.

Indexed as

Antipsychotic AgentsMental DisordersPsychiatryPsychopharmacologyAdolescentChildHumansMedicaidPragmatic Clinical Trials as TopicUnited StatesAntipsychotic Agentsaccessibilityantipsychoticconsultingguidelines

Identifiers

PMID34256967
PMCPMC8566327

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.