ArticleThe American journal of pathology1987
Characterization of intestinal brush border cytoskeletal proteins of normal and neoplastic human epithelial cells. A comparison with the avian brush border.
Article in The American journal of pathology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Cell-Free Culture Supernatant ofMicroorganisms · 2024Article
- c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs.The Journal of experimental medicine · 2022Article
- Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.The Journal of pathology · 2019Article
- A novel function for the MAP kinase SMA-5 in intestinal tube stability.Molecular biology of the cell · 2016Article
- Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney.PloS one · 2016Article
- Immunolocalization of protein 4.1B in the rat digestive system.Journal of molecular histology · 2004Article
- Effect of gastrin on differentiation of rat intestinal epithelial cells in vitro.World journal of gastroenterology · 2003Article
- MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells.Biophysical journal · 2002Article
- Autoantibodies specific for villin found in patients with colon cancer and other colitides.Digestive diseases and sciences · 1995Article
- A sialoglycoprotein complex linked to the microvillus cytoskeleton acts as a receptor for pilus (AF/R1) mediated adhesion of enteropathogenic Escherichia coli (RDEC-1) in rabbit small intestine.The Journal of cell biology · 1991Article
- Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues.The American journal of pathology · 1991Article
- Fodrin as a differentiation marker. Redistributions in colonic neoplasia.The American journal of pathology · 1989Article
- Role of calcium and calmodulin in the regulation of the rabbit ileal brush-border membrane Na+/H+ antiporter.The Journal of membrane biology · 1989Article
- Villin expression in the visceral endoderm and in the gut anlage during early mouse embryogenesis.The EMBO journal · 1988Article
- Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity.The Journal of cell biology · 1988Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The elaborate cytoskeletal matrix underlying the intestinal epithelial cell brush border (BB) is the hallmark of a mature enterocyte. As such, alterations in this structure are potentially useful as markers aiding in the recognition of subtle defects in cell maturation, such as those accompanying dysplasia and neoplasia. For exploration of this hypothesis, the BB components of human ileal and colonic enterocytes have been compared structurally and biochemically with the well-characterized avian BB, and alterations in the BB cytoskeleton in various states of dysplasia and neoplasia have been identified. Ultrastructural analysis of isolated human ileal BBs indicate that the human BB is structurally homologous to BBs isolated from chicken and other mammalian sources. Like other mammalian BBs (eg, from rat) the terminal web cytoskeleton of the human BB is less extensive than that in the avian BB. Immunochemical analysis of isolated human BBs indicates that the major proteins of the avian microvillar actin bundle, villin, fimbrin, and the 110-kd subunit of the 110K-calmodulin complex, are all present in the human BB. The terminal web protein myosin is also present. Unlike the terminal web of the avian BB, which contains a BB-specific isoform of spectrin, TW 260/240, the human BB contains the more widely distributed spectrin isoform, fodrin. In addition, the human BB contains multiple proteins immunoreactive with antibodies to protein 4.1, a spectrin/actin binding protein that is absent from the avian BB. Immunolocalization studies examining the distribution of the BB-specific microvillar protein, villin, in human colonic mucosa indicate that the localization of this protein is disrupted in certain dysplastic and neoplastic states. Thus, both the expression and/or distribution of BB-specific proteins such as villin may be useful markers for defects in the differentiation state of the enterocyte.
Indexed as
Identifiers
3425692PMC1899811W1728123378What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.