Evidence map›Paper›PMID 34256904›Full record

ArticleCancer cell2021

Cavity macrophages stop anti-tumor T cells.

Paulo C Rodriguez, Brian Ruffell

Open access · bronzeAbstract readComment
In one paragraph

Article in Cancer cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paulo C RodriguezDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. Electronic address: Paulo.Rodriguez@moffitt.org.
Brian RuffellDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA; Department of Breast Oncology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. Electronic address: Brian.Ruffell@moffitt.org.
Moffitt Cancer Center · US

Funding

Project 4P01CA250984 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$10.1M
Translational Genomics CoreP30GM114732 · NIGMS · LSU HEALTH SCIENCES CENTER · PI OCHOA, AUGUSTO C. · 2015 to 2019
$5.2M
Plant-derived extracts regulate immunosuppressive myelopoiesis in Breast cancer patientsR01CA262121 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$2.1M
Regulation of dendritic cell function and tumor immunity by TIM-3R01CA230610 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RUFFELL, BRIAN · 2019 to 2023
$2.0M
Functional reprogramming of tumor-MDSC through antibody-based therapies targeting Notch ligandsR01CA233512 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2019 to 2023
$2.0M
Stress Pathways in Tumors Drive Global MDSC Activity and Survival through ChopR01CA184185 · NCI · LSU HEALTH SCIENCES CENTER · PI RODRIGUEZ, PAULO CESAR · 2015 to 2019
$1.8M
Regulating Intratumoral Leukocytes to Improve Response to ChemotherapyR00CA185325 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RUFFELL, BRIAN · 2015 to 2017
$752k
NCI NIH HHS R00 CA185325NCI NIH HHS R01 CA184185NCI NIH HHS R01 CA230610NCI NIH HHS R01 CA233512NCI NIH HHS R01 CA262121NIGMS NIH HHS P30 GM114732
6 · The paper itself

Abstract

Precisely how macrophages regulate response to immunotherapy remains unclear. In this issue of Cancer Cell, Chow et al. demonstrate a tumor-promoting role of TIM-4

Indexed as

Hepatitis A Virus Cellular Receptor 2T-Lymphocytes, RegulatoryImmunotherapyMacrophagesT-Lymphocytes, CytotoxicHepatitis A Virus Cellular Receptor 2

Identifiers

PMID34256904
PMCPMC12801405
OpenAlexW3180808376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.