Evidence map›Paper›PMID 34256833›Full record

ArticleStem cell research & therapy2021

Scintigraphic tracking of

Charlotte Beerts, Carlien Brondeel, Glenn Pauwelyn, Eva Depuydt, Liesa Tack, Luc Duchateau, Yangfeng Xu, Jimmy H Saunders, Kathelijne Peremans, Jan H Spaas

Open access · goldAbstract read
In one paragraph

Article in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. The Biodistribution ofVeterinary sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Charlotte Beerts *Global Stem cell Technology NV, Noorwegenstraat 4, 9940, Evergem, Belgium.
Carlien Brondeel *Department of Medical Imaging and Orthopedics of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
Glenn PauwelynGlobal Stem cell Technology NV, Noorwegenstraat 4, 9940, Evergem, Belgium.
Eva DepuydtGlobal Stem cell Technology NV, Noorwegenstraat 4, 9940, Evergem, Belgium.
Liesa TackGlobal Stem cell Technology NV, Noorwegenstraat 4, 9940, Evergem, Belgium.
Luc DuchateauBiometrics Research Center, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
Yangfeng XuDepartment of Medical Imaging and Orthopedics of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
Jimmy H SaundersDepartment of Medical Imaging and Orthopedics of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
Kathelijne PeremansDepartment of Medical Imaging and Orthopedics of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
Jan H SpaasGlobal Stem cell Technology NV, Noorwegenstraat 4, 9940, Evergem, Belgium. jan.spaas@boehringer-ingelheim.com.ORCID 0000-0002-6683-2593
Ghent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cell treatments in dogs have been investigated as a potential innovative alternative to current conventional therapies for a variety of conditions. So far, the precise mode of action of the MSCs has yet to be determined. The aim of this study was to gain more insights into the pharmacokinetics of MSCs by evaluating their biodistribution in healthy dogs after different injection routes.

methodsThree different studies were performed in healthy dogs to evaluate the biodistribution pattern of radiolabelled equine peripheral blood-derived mesenchymal stem cells following intravenous, intramuscular and subcutaneous administration in comparison with free

resultsThe labelling efficiency ranged between 59.58 and 83.82%. Free

conclusionsA distinct difference was noted in the biodistribution pattern of the radiolabelled equine peripheral blood-derived mesenchymal stem cells compared to free

Indexed as

Mesenchymal Stem CellsAnimalsDogsHorsesInjections, IntravenousInjections, SubcutaneousTechnetiumTissue DistributionTechnetiumBiodistributionCanineEquine peripheral bloodMesenchymal stem cellsScintigraphyXenogeneic

Identifiers

PMID34256833
PMCPMC8278733
OpenAlexW3180030645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.