Evidence map›Paper›PMID 34256772›Full record

ArticleJournal of translational medicine2021

tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4

Guannan Geng, Huijing Wang, Weiwei Xin, Zhe Liu, Jie Chen, Zhang Danting, Fei Han, Shuang Ye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. Transfer RNA Fragments in Diseases of Sensory Organs.International journal of molecular sciences · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. A primer on tRNAs, tRNA-mFrontiers in cell and developmental biology · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. The Role of Extracellular Vesicles in Systemic Lupus Erythematosus.Frontiers in cell and developmental biology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Guannan Geng *Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Huijing Wang *Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Weiwei XinDepartment of Orthopaedics, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhe LiuDepartment of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jie ChenDepartment of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhang DantingDepartment of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Fei HanKey Laboratory of Kidney Disease Prevention and Control Technology, Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Hangzhou, China.
Shuang YeDepartment of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. ye_shuang2000@163.com.
Renji Hospital · CNCenter for Excellence in Brain Science and Intelligence Technology · CNFirst Affiliated Hospital Zhejiang University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs in CD4

methodsFirst, small RNA sequencing was performed on CD4

resultsWe identified 482 differentially expressed tRFs from SLE CD4

conclusionsOur study is the first to link aberrant tRF expression and SLE. tRF-3009 may participate in metabolic modulation of IFN-α-induced CD4

Indexed as

Lupus Erythematosus, SystemicOxidative PhosphorylationCD4-Positive T-LymphocytesHumansInterferon-alphaRNA, TransferInterferon-alphaRNA, TransferCD4+ T cellsOxidative phosphorylation (OXPHOS)Systemic lupus erythematosus (SLE)tRNA derived fragments (tRFs)Type I interferon (IFN)

Identifiers

PMID34256772
PMCPMC8278670
OpenAlexW3180382130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.