Evidence map›Paper›PMID 34256725›Full record

Trial reportBMC public health2021

Thetha Nami: participatory development of a peer-navigator intervention to deliver biosocial HIV prevention for adolescents and youth in rural South Africa.

Maryam Shahmanesh, Nonhlanhla Okesola, Natsayi Chimbindi, Thembelihle Zuma, Sakhile Mdluli, Nondumiso Mthiyane, Oluwafemi Adeagbo, Jaco Dreyer, Carina Herbst, Nuala McGrath and 3 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04532307 (Isisekelo Sempilo), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04532307 nacompletednot on this map

Isisekelo Sempilo: HIV Prevention Embedded in Sexual Health: A Pilot Trial to Optimize Peer (Thetha Nami) Delivery of HIV Prevention and Care to Adolescents and Young Adults in Rural KwaZulu-Natal.

TypeinterventionalSponsorAfrica Health Research InstituteRan2020 to 2022Enrolled1,743ConditionsHIV PreventionArmsStandard of Care SOC, SRH enhanced Isisekelo Sempilo, Peer-support (Thetha-Nami), SOC + SRH + peer-support
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Maryam ShahmaneshAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa. m.shahmanesh@ucl.ac.uk.ORCID 0000-0001-7129-8535
Nonhlanhla OkesolaAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Natsayi ChimbindiAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Thembelihle ZumaAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Sakhile MdluliAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Nondumiso MthiyaneAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Oluwafemi AdeagboAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Jaco DreyerAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Carina HerbstAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Nuala McGrathAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Guy HarlingAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Lorraine SherrInstitute for Global Health, University College London, Capper Street, London, WC1E 6JB, UK.
Janet SeeleyAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Africa Health Research Institute · ZAHarvard University · USLondon School of Hygiene & Tropical Medicine · GBUniversity College London · GBUniversity of Johannesburg · ZA

Funding

Maximizing combination HIV prevention, uptake and retention by adolescent girls and young womenR01MH114560 · NIMH · KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV · PI SHAHMANESH, MARYAM · 2017 to 2023
$2.0M
NIMH NIH HHS R01 MH114560Wellcome Trust 082384/Z/07/ZWellcome Trust 210479/Z/18/Z
6 · The paper itself

Abstract

backgroundDespite effective biomedical tools, HIV remains the largest cause of morbidity/mortality in South Africa - especially among adolescents and young people. We used community-based participatory research (CBPR), informed by principles of social justice, to develop a peer-led biosocial intervention for HIV prevention in KwaZulu-Natal (KZN).

methodsBetween March 2018 and September 2019 we used CBPR to iteratively co-create and contextually adapt a biosocial peer-led intervention to support HIV prevention. Men and women aged 18-30 years were selected by community leaders of 21 intervention implementation areas (izigodi) and underwent 20 weeks of training as peer-navigators. We synthesised quantitative and qualitative data collected during a 2016-2018 study into 17 vignettes illustrating the local drivers of HIV. During three participatory intervention development workshops and community mapping sessions, the peer-navigators critically engaged with vignettes, brainstormed solutions and mapped the components to their own izigodi. The intervention components were plotted to a Theory of Change which, following a six-month pilot and process evaluation, the peer-navigators refined. The intervention will be evaluated in a randomised controlled trial ( NCT04532307 ).

resultsFollowing written and oral assessments, 57 of the 108 initially selected participated in two workshops to discuss the vignettes and co-create the Thetha Nami (`talk to me'). The intervention included peer-led health promotion to improve self-efficacy and demand for HIV prevention, referrals to social and educational resources, and aaccessible youth-friendly clinical services to improve uptake of HIV prevention. During the pilot the peer-navigators approached 6871 young people, of whom 6141 (89%) accepted health promotion and 438 were linked to care. During semi-structured interviews peer-navigators described the appeal of providing sexual health information to peers of a similar age and background but wanted to provide more than just "onward referral". In the third participatory workshop 54 peer-navigators refined the Thetha Nami intervention to add three components: structured assessment tool to tailor health promotion and referrals, safe spaces and community advocacy to create an enabling environment, and peer-mentorship and navigation of resources to improve retention in HIV prevention.

conclusionLocal youth were able to use evidence to develop a contextually adapted peer-led intervention to deliver biosocial HIV prevention.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsAdolescentFemaleHumansMalePeer GroupRural PopulationSexual BehaviorSouth AfricaAdolescentsCommunity-based participatory researchHealth promotionHIVPeer-ledPre-exposure prophylaxisSexual healthSocial capitalSouth AfricaYoung people

Identifiers

PMID34256725
PMCPMC8278686
OpenAlexW3154916838

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.