Evidence map›Paper›PMID 34256713›Full record

ArticleBMC cancer2021

Distinct nitrogen isotopic compositions of healthy and cancerous tissue in mice brain and head&neck micro-biopsies.

M Straub, D M Sigman, A Auderset, J Ollivier, B Petit, B Hinnenberg, F Rubach, S Oleynik, M-C Vozenin, A Martínez-García

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05494359 (The Diagnostic Value of Various Mass Nitrogen Components Excreting for Oral Gas in Esophagus Cancer), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05494359 completednot on this mapstarted 2023, after this paper: background citation

The Diagnostic Value of Various Mass Nitrogen Components Excreting for Oral Gas in Esophagus Cancer

TypeobservationalSponsorHepatopancreatobiliary Surgery Institute of Gansu ProvinceRan2023 to 2024Enrolled120ConditionsEsophageal CancerArmsThe nitrogen isotope
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Nitrogen Isotope Effects in Urea Metabolism: From Biochemistry toInternational journal of molecular sciences · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M StraubInstitute of Radiation Physics, Lausanne University Hospital and University of Lausanne, 1007 Lausanne, Switzerland. marietta.straub@chuv.ch.ORCID https://orcid.org/0000-0002-1156-4085
D M SigmanDepartment of Geosciences, Princeton University, Princeton, NJ, 08544, USA.
A AudersetMax Planck Institute for Chemistry, 55128, Mainz, Germany.
J OllivierRadiation Oncology Laboratory/DO/Radio-Oncology/CHUV, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
B PetitRadiation Oncology Laboratory/DO/Radio-Oncology/CHUV, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
B HinnenbergMax Planck Institute for Chemistry, 55128, Mainz, Germany.
F RubachMax Planck Institute for Chemistry, 55128, Mainz, Germany.
S OleynikDepartment of Geosciences, Princeton University, Princeton, NJ, 08544, USA.
M-C VozeninRadiation Oncology Laboratory/DO/Radio-Oncology/CHUV, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
A Martínez-GarcíaMax Planck Institute for Chemistry, 55128, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancerous cells can recycle metabolic ammonium for their growth. As this ammonium has a low nitrogen isotope ratio (

methodsMicro-biopsies of murine tumors and adjacent tissues were analyzed for

resultsIn the 7 mice analyzed, the brain tumors had distinctly lower

conclusionsThe findings, coupled with the high sensitivity of the

Indexed as

AnimalsBiopsyBrainCase-Control StudiesDisease Models, AnimalHead and Neck NeoplasmsHumansMiceMice, NudeNitrogen IsotopesNitrogen IsotopesCell metabolismDiagnosticsMicro-biopsiesNitrogen isotopes

Identifiers

PMID34256713
PMCPMC8276491

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.