ArticleBMC cardiovascular disorders2021
Current status and etiology of valvular heart disease in China: a population-based survey.
Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07256197 (Effect and Safety of PCSK9 Inhibitors on the Progression of Mild/Middle Calcific Aortic Stenosis), which is not on this map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect and Safety of PCSK9 Inhibitors on the Progression of Mild/Middle Calcific Aortic Stenosis: A Randomized Controlled Clinical Trial
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Exercise-Based Cardiac Rehabilitation for Patients After Heart Valve Surgery: A Systematic Review and Re-Evaluation With Evidence Mapping Study.Clinical cardiology · 2025Pooled it
- Impact of RAS inhibitors on 2-year mortality and disease progression in chronic mitral regurgitation.BMC cardiovascular disorders · 2026Article
- Plasma aldosterone concentration and valvular heart disease in hypertensive patients: a large cross-sectional study.Scientific reports · 2026Article
- Gender differences in clinical profiles, management and outcomes of valvular heart disease in China: insights from a nationwide cohort.BMJ open · 2026Article
- Clinical efficacy of transcatheter aortic valve replacement in patients with rheumatic aortic stenosis.BMC cardiovascular disorders · 2026Article
- Clinical outcomes and management strategies for moderate aortic regurgitation in patients undergoing rheumatic mitral valve surgery.Scientific reports · 2026Observational
- Preoperative LDL-C and mortality after cardiac valve surgery: a retrospective cohort study on the mediating role of inflammatory risk.Lipids in health and disease · 2026Article
- Nomogram prediction model for pneumonia after valve replacement in patients with heart valve disease.Frontiers in cardiovascular medicine · 2026Article
- A case report: Transcatheter aortic valve replacement via femoral artery for aortic regurgitation post-CARVAR.Frontiers in cardiovascular medicine · 2026Article
- Efficacy and safety of transcatheter aortic valve replacement for the treatment of pure severe native aortic valve regurgitation: a single-arm meta-analysis.Frontiers in medicine · 2026Article
- ScienCrown Valve: A Novel Transcatheter Heart Valve for Concurrent Aortic and Mitral Valve-in-Valve Implantation in Bioprosthetic Degeneration.Anatolian journal of cardiology · 2025Article
- Automatic Diagnosis of Left Valvular Heart Disease Based on Artificial Intelligence Stethoscope.JACC. Advances · 2025Article
- Prevalence, spectrum and aetiology of valvular heart disease based on community echocardiographic screening transition from different altitudes in Yunnan, China.Heart (British Cardiac Society) · 2025Article
- The evolving burden of heart failure in China: a 34-year subnational analysis of trends and causes from the Global Burden of Disease Study 2023.Military Medical Research · 2025Article
- Rationale and Design of the EPISODE Trial: A Randomized Controlled Trial on the Effect of PCSK9 Inhibitors in Calcific Aortic Valve Stenosis.Journal of the American Heart Association · 2025Article
- The Valvular Heart Disease-specific Age-adjusted Comorbidity Index (VHD-ACI) score in patients with moderate or severe valvular heart disease.Journal of geriatric cardiology : JGC · 2025Article
- [Clinical efficacy and safety of transcatheter aortic valve replacement for patients with severe pure native aortic regurgitation].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Article
- Valvular heart disease and associated factors among adult cardiac patients in a tertiary hospital, Ethiopia.BMC cardiovascular disorders · 2025Article
- Comparison of incidence, prevalence and death of aortic stenosis and aortic insufficiency in a nationwide Korean study.ESC heart failure · 2025Article
- Transcatheter Intervention for Multiple Valve Diseases in a Patient With Cardiogenic Shock.JACC. Case reports · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe epidemiology of valvular heart disease (VHD) has changed markedly over the last 50 years worldwide, and the prevalence and features of VHD in China are unknown. The objective of this study was to investigate the current status and etiology of VHD in China.
methodsWe used a cross-sectional national survey with stratified multistage random sampling from the general Chinese population to estimate the VHD burden. Data on demographic characteristics, medical history, physical examination, blood tests, and potential etiology were collected. Echocardiography was used to detect VHD.
resultsThe national survey enrolled 34,994 people aged 35 years or older across China. Overall, 31,499 people were included in the final analysis, and 1309 participants were diagnosed with VHD. The weighted prevalence was 3.8%, with an estimated 25 million patients in China. The prevalence of VHD increased with age and was higher in participants with hypertension or chronic kidney disease than in their counterparts. Among participants with VHD, 55.1% were rheumatic and 21.3% were degenerative. The proportion of rheumatic decreased with age, and the proportion of degenerative rose with age. However, the prevalence of rheumatic disease was still higher in the elderly population than in the younger population. Logistic regression revealed that age and hypertension were correlated with VHD.
conclusionsIn China, rheumatic heart disease was still the major cause of the VHD, with a significant increase in degenerative heart disease. Age and hypertension are important and easily identifiable markers of VHD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.